This study was conducted to determine the outcome of patients who develop a second
neoplasm after radiotherapy (RT) for a childhood solid tumor. From 1956 to 1998, 429 …

Currently, approximately 67% of children diagnosed with cancer can be expected to survive
more than 5 years. Among the most significant late effects of cancer therapy is the …

As the cure rate for childhood malignancies increases, the number of patients at risk for
development of second malignancies also increases. Due to the potentially long remaining …

This paper presents an update from the Late Effects Study Group on 292 cases of second
malignant neoplasms (SMN) occurring in individuals who were diagnosed with their first …

BACKGROUND Because ionizing radiation is a known carcinogen, diligent long‐term follow‐
up in children exposed to therapeutic radiation is required. The authors updated an earlier …

To investigate the incidence and outcome of secondary neoplasms in pediatric patients
treated for childhood cancer. Between December 1971 and January 2000, a total of 5859 …

Although the incidence of childhood cancer has stabilized over the past few years,
approximately 12,000 new cases are diagnosed each year in the United States among …

Among a cohort of 9,279 survivors of childhood neoplasms other than retinoblastoma
treated in Britain before 1980, the cumulative risk of a second primary tumor (SPT) by 25 …

Purpose: Radiation-induced osteosarcomas (R-OS) have historically been high-grade,
locally invasive tumors with a poor prognosis. The purpose of this study was to perform a …

PURPOSE: To compare patterns of long-term deaths due to secondary carcinomas,
sarcomas, and hematological malignancies occurring after childhood cancer in a cohort of …