[HTML][HTML] Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein (a) in 10,910 individuals
S Di Maio, R Grüneis, G Streiter, C Lamina… - Genome medicine, 2020 - Springer
Background The concentrations of the highly atherogenic lipoprotein (a)[Lp (a)] are mainly
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …
[HTML][HTML] A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region [S]
Lipoprotein (a)[Lp (a)] concentrations are among the strongest genetic risk factors for
cardiovascular disease and present pronounced interethnic and interindividual differences …
cardiovascular disease and present pronounced interethnic and interindividual differences …
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
Lack of association of rs3798220 with small apolipoprotein (a) isoforms and high lipoprotein (a) levels in East and Southeast Asians
M Khalifa, A Noureen, K Ertelthalner, AR Bandegi… - Atherosclerosis, 2015 - Elsevier
Objective The variant allele of rs3798220 in the apolipoprotein (a) gene (LPA) is used to
assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with …
assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with …
[HTML][HTML] Deep coverage whole genome sequences and plasma lipoprotein (a) in individuals of European and African ancestries
SM Zekavat, S Ruotsalainen, RE Handsaker… - Nature …, 2018 - nature.com
Abstract Lipoprotein (a), Lp (a), is a modified low-density lipoprotein particle that contains
apolipoprotein (a), encoded by LPA, and is a highly heritable, causal risk factor for …
apolipoprotein (a), encoded by LPA, and is a highly heritable, causal risk factor for …
Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease
JF Schachtl-Riess, A Kheirkhah, R Grüneis… - Journal of the American …, 2021 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) concentrations are a major independent risk
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …
Kringle IV type 2, not low lipoprotein (a), as a cause of diabetes: a novel genetic approach using SNPs associated selectively with lipoprotein (a) concentrations or with …
A Tolbus, MB Mortensen, SF Nielsen… - Clinical …, 2017 - academic.oup.com
BACKGROUND Low plasma lipoprotein (a) concentrations are associated with type 2
diabetes. Whether this is due to low lipoprotein (a) concentrations per se or to a large …
diabetes. Whether this is due to low lipoprotein (a) concentrations per se or to a large …
[HTML][HTML] The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat
R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
Abstract Lipoprotein (a)[Lp (a)] concentrations are regulated by the LPA gene mainly via the
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …
Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels
W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …