Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Reactive oxygen species (ROS) and the cellular thiol redox state are crucial mediators of
multiple cell processes like growth, differentiation, and apoptosis. Excessive ROS production …

The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and
NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This …

The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Since their discovery as a substrate for ribonucleotide reductase (RNR), the role of
thioredoxin (Trx) and glutaredoxin (Grx) has been largely extended through their regulatory …

Studies on thioredoxin (Trx) and its related molecules have expanded dramatically recently.
Proteins that share the similar active-site sequence,-Cys-Xxx-Yyy-Cys-, are called the Trx …

Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and
peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes …

Reactive oxygen species (ROS) are not only cytotoxic products from external and internal
environment, but also important mediators of redox signaling. Therefore, thioredoxin (Trx) as …

Reactive oxygen species (ROS) are known to be mediators of intracellular signaling
pathways. However the excessive production of ROS may be detrimental to the cell as a …

Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …