Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme …
H Schächinger, T Dieterle, B Martina… - Journal of …, 2004 - journals.lww.com
Results Before chronic ACE inhibition, A2 increased mean arterial blood pressure (FH+,
8.7±0.8 mmHg; FH−, 8.9±0.9 mmHg), plasma immunoreactive A2 (FH+, 21±2 pg/ml; FH …
8.7±0.8 mmHg; FH−, 8.9±0.9 mmHg), plasma immunoreactive A2 (FH+, 21±2 pg/ml; FH …
Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension
MP Schlaich, AU Klingbeil, J Jacobi… - Journal of …, 2002 - journals.lww.com
Objective An increased sensitivity to angiotensin II (Ang II) has been observed in patients
with established hypertension. In the current study we tested whether young normotensive …
with established hypertension. In the current study we tested whether young normotensive …
Angiotensin I to angiotensin II conversion in the human forearm and leg. Effect of the angiotensin converting enzyme gene insertion/deletion polymorphism
AHJ Danser, J Deinum, APRM Osterop… - Journal of …, 1999 - journals.lww.com
Objective The angiotensin-converting enzyme (ACE) gene I/D polymorphism accounts for
part of the variation in ACE concentration; subjects with one or two D alleles have …
part of the variation in ACE concentration; subjects with one or two D alleles have …
Failure of angiotensin II to suppress plasma renin activity in normotensive subjects with a positive family history of hypertension
H Herlitz, E Palmgren, B Widgren, M Aurell - Clinical Science, 2005 - portlandpress.com
The renin–angiotensin system is implicated in the pathophysiology of hypertension. Renin
release is regulated by a number of factors, including circulating Ang II (angiotensin II), the …
release is regulated by a number of factors, including circulating Ang II (angiotensin II), the …
Increased systemic and renal vascular sensitivity to angiotensin II in normotensive men with positive family histories of hypertension
BR Widgren, H Herlitz, M Aurell… - American journal of …, 1992 - academic.oup.com
Normotensive young men (mean age 36 years) with positive (PFH)(n= 13) and negative (n=
29) family histories of hypertension were investigated in order to study systemic and renal …
29) family histories of hypertension were investigated in order to study systemic and renal …
Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade
W Spiering, AA Kroon, MJMJ Fuss-Lejeune… - Journal of …, 2005 - journals.lww.com
Objective Clinical observations point towards heterogeneity in patients' responses to
antihypertensive drugs. As our earlier work showed that angiotensin II (AngII) sensitivity is …
antihypertensive drugs. As our earlier work showed that angiotensin II (AngII) sensitivity is …
Intra-individual responses to blockade of the renin-angiotensin system by an ACE inhibitor (lisinopril) & an angiotensin receptor antagonist (candesartan)
PS Sever - American Journal of Hypertension, 2000 - academic.oup.com
Angiotensin receptor antagonists (AT1A) are recommended for hypertensive patients in
whom angiotensin converting enzyme inhibitors (ACEI) are effective but poorly tolerated. No …
whom angiotensin converting enzyme inhibitors (ACEI) are effective but poorly tolerated. No …
Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition
AD Hingorani, PA Stevens, MJ Brown, H Jia… - Journal of …, 1995 - journals.lww.com
Objectives: To investigate the relationship between polymorphisms in the angiotensin
converting enzyme (ACE), angiotensinogen (AGT) and type 1 angiotensin-II (AT1R) genes …
converting enzyme (ACE), angiotensinogen (AGT) and type 1 angiotensin-II (AT1R) genes …
Angiotensin I-converting enzyme gene polymorphism influences chronic hypertensive response in the rat Goldblatt model
MP Ocaranza, AM Piddo, P Faúndez… - Journal of …, 2002 - journals.lww.com
Methods and results Systolic BP (SBP), ACE and angiotensin II (Ang II) levels were
measured using the Goldblatt (Gb) model (two kidneys, one clip) in homozygous males of …
measured using the Goldblatt (Gb) model (two kidneys, one clip) in homozygous males of …
Genetically increased angiotensin I-converting enzyme alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice
C Chollet, S Placier, C Chatziantoniou… - American Journal …, 2018 - journals.physiology.org
Angiotensin I-converting enzyme (ACE) levels in humans are under strong genetic
influence. Genetic variation in ACE has been linked to risk for and progression of …
influence. Genetic variation in ACE has been linked to risk for and progression of …