Clinical management of breast cancer is increasingly guided by assessment of tumor
phenotypic parameters. One of these is estrogen receptor (ER) status, currently defined by …

The discovery of a second estrogen receptor (ER), ERβ, has led to a reevaluation of
estrogen action. The widespread expression of ERβ-like proteins in normal and neoplastic …

Though the role of Estrogen Receptor (ER) α in breast cancer has been studied extensively,
there is little consensus about the role of alternative ER isoform ERβ in breast cancer …

One of the main prognostic markers measured in breast tumours is oestrogen receptor (ER)
status. With the discovery of ERβ, it has been necessary to re-evaluate ER signalling and the …

Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …

Purpose Significant controversy exists regarding the expression patterns of estrogen
receptor beta (ERβ) in normal and diseased breast tissue. To address this issue, we have …

More than 10 years have passed since the discovery of the second estrogen receptor,
estrogen receptor β (ERβ). It is now evident that ERα is not the only ER in breast cancer …

Estrogen is essential for growth and development of the mammary glands and has been
associated with the promotion and growth of breast cancer and in line with this, most human …

The role of estrogen exposure in breast cancer risk is well-documented, and both estrogen
synthesis and actions through the estrogen receptor (ER) have been targeted by therapies …

Both subtypes of estrogen receptor (ER), ERα and ERβ, are normally present in the
mammary gland. The role of ERα as a prognostic marker in breast cancer is well established …