Multiple adhesion receptors are involved in the interaction of hematopoietic cells with the
marrow microenvironment. This work characterizes the expression of various adhesive …

HEMATOPOIESIS IS A complex process in which pluripo-tent stem cells proliferate and
differentiate to generate the full complement of mature blood cells. More than 30 …

Significant progress has been made recently in the understanding of cell adhesion
signaling. Many components of focal adhesion complexes have been identified in fibroblasts …

The CD11b/CD18 leukocyte integrin molecule mediates diverse neutrophil adherence-
related functions, including cell: cell and cell: extracellular matrix attachments. To study the …

Acute Lymphoblastic Leukemia (ALL) is the most common cancer in childhood. Despite a
significantly improved prognosis over the last decade with a 5-years survival rate of~ 90 …

Hematopoiesis takes place in close contact with the marrow microenvironment. Normal
progenitors adhere through a variety of receptors to stroma and extracellular matrix …

In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the
bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic …

Expression of selected adhesion molecules of the integrin and immunoglobulin family was
investigated on CD 34+ leukemic cells in 19 AML and 11 ALL cases to evaluate phenotypic …

Normal steady-state hematopoiesis takes place in the bone marrow microenvironment.
Soluble factors as well as contact interactions between the hematopoietic cells and the …

Associations between hematopoietic cells and their microenvironment are central to the
development and maintenance of a functional hematopoietic system. It is important …