Serotonin (5‐hydroxytryptamine; 5‐HT) 5‐HT2A and 5‐HT2C receptors belong to the class
of phosphoinositide‐specific phospholipase C (PLC)‐linked receptors. Conditions were …

SUMMARY A permanent line of cells has been established from the trans-plantable rat
pituitary tumor 731 5a. P1 1 cells have been cloned repeatedly, and after more than 60 …

Radioligand binding studies have revealed four distinct serotonin (5HT) binding sites in rat
brain that are thought to function as 5HT receptors. These include the 5HT-1a, 5HT-1b, 5HT …

The hypothesis that serotonin (5-HT)-stimulated phosphoinositide hydrolysis is mediated by
the 5-HT-2 binding site in cerebral cortex was tested by comparing antagonist Kd values …

Central 5-HT2 and 5-HT1C receptors appear to be relatively resistant to up-regulation. 5-
HT2 receptors are not upregulated after denervation of 5-HT neurons and chronic …

Evidence suggests that the serotonin 5HT-1 receptor site is functionally linked to adenylate
cyclase in the brain, but a biochemical effector system which is linked to the serotonin 5HT-2 …

MATTERS ARISING 317 vious claims that the 5-HT2 receptor is a two-state receptor were
correct, then both states should be demonstrable in any tissue containing the radiolabeled 5 …

In the presence of 1 μM (±)‐pindolol [to block 5‐hydroxytryptamine (5‐HT, serotonin) 5‐
HT1A and 5‐HT1B receptors] and 100 nM mesulergine (to block 5‐HT1C receptors), 2.0 nM …

Three pharmacologically distinct high‐affinity [3H] serotonin ([3H] 5‐HT) binding sites were
identified in spinal cord synaptosomes.[3H] 5‐HT competition studies using selective 5 …

Serotonin (5HT) binding sites in the medulla oblongata of the rat were localized using
autoradiographic techniques with radioactive ligands that express high affinity for the …