The development of intestinal permeability and the penetration of microbial products are key
factors associated with the onset of metabolic disease. However, the mechanisms …

Intestinal barrier dysfunction is an important contributor to alcoholic liver disease (ALD).
Translocated microbial products trigger an inflammatory response in the liver and contribute …

Background: A defective mucosal barrier function is the principal cause of the uncontrolled
onset and progression of a number of human inflammatory gut diseases, most of which are …

The prevalence of nonalcoholic fatty liver disease and the consequent burden of metabolic
syndrome have increased in recent years. Although the pathogenesis of nonalcoholic fatty …

Background Lipolysis is accelerated during the acute phase of inflammation, a process
being regulated by pro-inflammatory cytokines (eg TNF-α), stress-hormones, and insulin …

Background & Aims While it is widely accepted that obesity is associated with low-grade
systemic inflammation, the molecular origin of the inflammation remains unknown. Here, we …

Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of metabolic syndrome
and is the most common chronic liver disease in the world. The pathogenesis of NAFLD has …

The importance of the postprandial state has been acknowledged, since hyperglycemia and
hyperlipidemia are linked with several chronic systemic low-grade inflammation conditions …

The intestinal barrier, composed of the luminal microbiota, the mucus layer, and the physical
barrier consisting of epithelial cells and immune cells, the latter residing underneath and …

Crohn's disease and ulcerative colitis, phenotypically comprising a spectrum of inflammatory
bowel diseases (IBDs), spread globally during the westernization of lifestyle and dietary …