Early improvement is a predictor of treatment outcome in patients with mild major, minor or subsyndromal depression
A Tadić, I Helmreich, R Mergl, M Hautzinger… - Journal of Affective …, 2010 - Elsevier
BACKGROUND: There is substantial evidence that early improvement (EI) under
antidepressant treatment is a clinically useful predictor of later treatment outcome in patients …
antidepressant treatment is a clinically useful predictor of later treatment outcome in patients …
[HTML][HTML] Antidepressant response in major depressive disorder: a meta-regression comparison of randomized controlled trials and observational studies
F Naudet, AS Maria, B Falissard - PLoS One, 2011 - journals.plos.org
Background To compare response to antidepressants between randomized controlled trials
(RCTs) and observational trials. Methods and Findings Published and unpublished studies …
(RCTs) and observational trials. Methods and Findings Published and unpublished studies …
Early improvement under mirtazapine and paroxetine predicts later stable response and remission with high sensitivity in patients with major depression
A Szegedi, MJ Muller, I Anghelescu… - Journal of Clinical …, 2003 - psychiatrist.com
Objective: Current clinical knowledge holds that antidepressants have a delayed onset of
efficacy. However, the delayed onset hypothesis has been questioned recently by survival …
efficacy. However, the delayed onset hypothesis has been questioned recently by survival …
A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
AC Leon, DA Solomon, TI Mueller… - American Journal of …, 2003 - Am Psychiatric Assoc
OBJECTIVE: This observational study examined the effectiveness of somatic antidepressant
treatments as administered in the community. METHOD: The study group consisted of 285 …
treatments as administered in the community. METHOD: The study group consisted of 285 …
Is switching antidepressants following early nonresponse more beneficial in acute-phase treatment of depression?: a randomized open-label trial
S Nakajima, H Uchida, T Suzuki, K Watanabe… - Progress in Neuro …, 2011 - Elsevier
RATIONALE: Treatment guidelines for major depressive disorder (MDD) recommend a
continuous use of antidepressants for several weeks, while recent meta-analyses indicate …
continuous use of antidepressants for several weeks, while recent meta-analyses indicate …
Time course of response to antidepressants: predictive value of early improvement and effect of additional psychotherapy
D van Calker, I Zobel, P Dykierek, CM Deimel… - Journal of Affective …, 2009 - Elsevier
BACKGROUND: The full response to antidepressant pharmacotherapy is evident only after
several weeks, but considerable improvements may already be visible within the first two …
several weeks, but considerable improvements may already be visible within the first two …
Factors associated with failure to achieve remission and with relapse after remission in patients with major depressive disorder in the PERFORM study
D Saragoussi, M Touya, JM Haro… - Neuropsychiatric …, 2017 - Taylor & Francis
Background The Prospective Epidemiological Research on Functioning Outcomes Related
to Major Depressive Disorder (PERFORM) study has been initiated to better understand the …
to Major Depressive Disorder (PERFORM) study has been initiated to better understand the …
Delayed onset of action of antidepressant drugs? Survey of recent results
HH Stassen, J Angst, A Delini-Stula - European psychiatry, 1997 - cambridge.org
The onset of action of antidepressant drugs was investigated on the basis of two
independent multicenter, double-blind efficacy studies comparing amitriptyline (n= 120) …
independent multicenter, double-blind efficacy studies comparing amitriptyline (n= 120) …
Onset, time course and trajectories of improvement with antidepressants
RW Lam - European Neuropsychopharmacology, 2012 - Elsevier
There is still considerable controversy about the onset and time course of improvement with
antidepressants in the treatment of major depressive disorder. Previous studies suggested a …
antidepressants in the treatment of major depressive disorder. Previous studies suggested a …
[HTML][HTML] Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration
Background Meta-analyses of antidepressant medications have reported only modest
benefits over placebo treatment, and when unpublished trial data are included, the benefit …
benefits over placebo treatment, and when unpublished trial data are included, the benefit …