We conducted a secondary analysis of data from the Prevention of Recurrent Episodes of
Depression With Venlafaxine Extended Release (ER) for Two Years (PREVENT) trial to …

The goal of treatment of major depression should be full remission. Many patients, however,
fail to achieve or maintain symptom-free status. Residual depressive symptoms are …

As treatment outcome in depression varies widely, it is important to understand better the
predictive value of particular patient characteristics. However, qualitative systematic reviews …

Several often-cited meta-analyses have reported that the efficacy of antidepressant
medications depends on the severity of depression. They found that drug–placebo …

Background It remains unclear regarding the contribution of each individual symptom in
predicting the outcome in major depressive disorder (MDD). The objective of this analysis …

Objective: To evaluate the efficacy and tolerability of dose increase compared to dose
continuation of the initially prescribed antidepressant in antidepressant treatment failure …

Objective: To underscore the need to attain remission in the treatment of depression, taking
into consideration the appropriate definitions of response and remission, as well as the …

BACKGROUND: To examine the predictive value of early response for final outcome of
psychotherapy and combined therapy in major depression. METHODS: Mild-to moderately …

In the treatment of depression, there is considerable interest in the time course of response
and, in particular, the speed with which individuals recover from depressive episodes …

Although increased pre-treatment severity of depressive symptoms is thought to suggest
better outcome with tricyclic antidepressants, it is unclear if such a pattern exists among …