Context Antidepressant medications represent the best established treatment for major
depressive disorder, but there is little evidence that they have a specific pharmacological …

Background Depression is one of the prevalent mental illnesses and leading cause of global
disease burden. However, most people with depression do not access treatment. Remission …

Remission and response were suggested as the most relevant outcome criteria for the
treatment of depression. There is still marked uncertainty as to what cut-offs should be used …

The authors examined the effect of psychosocial and clinical variables on treatment
response trajectory in elderly patients with major depressive disorder. Three studies …

Major depression is often a relapsing disorder. It is therefore important to start its treatment
with therapies that maximize the chance of not only getting the patients well but also keeping …

BackgroundAlthough many studies suggest that, on average, depression-specific
psychotherapy and antidepressant pharmacotherapy are efficacious, we know relatively little …

Current gold standard approaches to the treatment of depression include
pharmacotherapeutic and psychotherapeutic interventions with social support. Due to …

Background: Symptomatic remission is the optimal outcome in depression. A brief, validated
tool for symptom measurement that can indicate when remission has occurred in mental …

Knowledge on mechanisms involved in early prediction of response to antidepressant
medication may help optimize clinical decision making. Recent studies regarding response …

Background: Although active maintenance treatments appear superior to placebo in
preventing depression recurrence in older adults, few data are available to guide …