The development of new compounds with greater cancer inhibitory activity and that are well
tolerated continues to be a priority in chemoprevention research involving selenium. One …

A major research goal of our laboratories is the development of new organoselenium cancer
chemopreventive agents with less toxicity compared to some of the historical selenium …

To explore cellular effects of potent organoselenium chemo‐preventive agents we have
used a rat mammary tumor cell line. We demonstrate that 1, 4‐phenylenebis (methylene) …

Methylated selenides are prominent metabolites at the dietary levels used for obtaining
anticarcinogenic effects with selenium. The present study reports the chemopreventive …

The present study compared the effects of four lipophilic forms of selenium with regard to
cancer chemopreventive activity, tissue selenium accumulation, and bioavailability for …

Cancer chemoprevention by high levels of selenium, including compounds like sodium
selenite or selenomethionine, is generally not accompanied by increases in known …

Triphenylselenonium chloride, a novel synthetic organic selenium compound in which
selenium is bonded to three unsubstituted benzene rings, possesses significant …

The anticarcinogenic activity of selenium in animal models is well established. The active
forms of selenium involved have not been identified to date, but conversion of selenium via …

Several organoselenlum compounds have been shown to have powerful anticarcinogenic
activity. In view of certain similarities between selenium and sulfur biochemistry, we have …

Experimental studies with rodents indicate that selenium supplementation at levels above
the dietary requirement is capable of protecting against tumorigenesis induced by chemical …