Small cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+ cells in tumour infiltrate

W Wang, P Hodkinson, F McLaren… - … Journal of Cancer, 2012 - Wiley Online Library
Small cell lung cancer (SCLC) kills at least one person every 2 hr in the United Kingdom.
Some patients do relatively well but most have rapidly progressive disease. There is no …
被引用次数：111 相关文章 所有 8 个版本

Elevated Circulating CD4+CD25−Foxp3+ Regulatory T Cells in Patients with Nonsmall Cell Lung Cancer

X Hu, Y Gu, S Zhao, S Hua, Y Jiang - Cancer Biotherapy & …, 2019 - liebertpub.com
Abstract Purpose: CD4+ CD25+ Foxp3+ regulatory T (Treg) cell-mediated
immunosuppression has been implicated as a crucial mechanism of tumor immune cell …
被引用次数：29 相关文章 所有 3 个版本

The Prevalence of FOXP3+ Regulatory T-Cells in Peripheral Blood of Patients with NSCLC

L Li, QG Chao, LZ Ping, C Xue, ZY Xia… - Cancer Biotherapy …, 2009 - liebertpub.com
We have studied CD4+ CD25highFOXP3+ regulatory T-cells (Tregs) from 51 patients with
non–small-cell lung cancer (NSCLC) and 33 healthy donors. Regulatory T-cells were …
被引用次数：66 相关文章 所有 6 个版本
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[HTML][HTML] The prognostic role of circulating CD8+ T cell proliferation in patients with untreated extensive stage small cell lung cancer

N An, H Wang, W Jia, W Jing, C Liu, H Zhu… - Journal of translational …, 2019 - Springer
Background Immunosuppression caused by tumorigenesis may promote tumor progress
and invasion. Here, we investigated whether the characteristics of circulating T lymphocyte …
被引用次数：34 相关文章 所有 11 个版本
[HTML] sciencedirect.com

[HTML][HTML] Foxp3+ regulatory T cells and natural killer cells distinctly infiltrate primary tumors and draining lymph nodes in pulmonary adenocarcinoma

T Schneider, S Kimpfler, A Warth, PA Schnabel… - Journal of thoracic …, 2011 - Elsevier
Introduction: Regulatory T cells (Tregs) can play a key role in suppressing T-cell-mediated
immunity in patients with cancer. In this study, the immune cell composition of the lung tissue …
被引用次数：93 相关文章 所有 6 个版本

Reciprocal CD4+ T-Cell Balance of Effector CD62Llow CD4+ and CD62LhighCD25+ CD4+ Regulatory T Cells in Small Cell Lung Cancer Reflects Disease …

K Koyama, H Kagamu, S Miura, T Hiura… - Clinical cancer …, 2008 - AACR
Purpose: Small cell lung cancer (SCLC) possesses high tendency to disseminate. However,
SCLC patients with paraneoplastic syndrome mediated by immunity against onconeural …
被引用次数：170 相关文章 所有 7 个版本
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Tumor infiltrating Foxp3+ regulatory T‐cells are associated with recurrence in pathologic stage I NSCLC patients

RP Petersen, MJ Campa, J Sperlazza, D Conlon… - Cancer, 2006 - Wiley Online Library
BACKGROUND. Early stage lung cancer has a variable prognosis, and there are currently
no markers that predict which patients will recur. This study examined the relation between …
被引用次数：550 相关文章 所有 9 个版本
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[HTML][HTML] Increase in activated Treg in TIL in lung cancer and in vitro depletion of Treg by ADCC using an antihuman CCR4 mAb (KM2760)

K Kurose, Y Ohue, E Sato, A Yamauchi… - Journal of Thoracic …, 2015 - Elsevier
Introduction Tregs infiltrate tumors and inhibit immune responses against them. Methods We
investigated subpopulations of Foxp3+ CD4 T cells previously defined by Miyara et …
被引用次数：58 相关文章 所有 8 个版本
[PDF] academia.edu

Foxp3 expressing CD4+ CD25+ and CD8+ CD28− T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma

F Meloni, M Morosini, N Solari, I Passadore… - Human immunology, 2006 - Elsevier
The role of T regulatory (Treg) cells in human cancer has not yet been clarified. We
assessed the presence and function of CD4+ and CD8+ Treg cell subsets in the peripheral …
被引用次数：232 相关文章 所有 12 个版本
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[HTML][HTML] The role of immune microenvironment in small-cell lung cancer: distribution of PD-L1 expression and prognostic role of FOXP3-positive tumour infiltrating …

L Bonanno, A Pavan, MV Dieci, E Di Liso… - European journal of …, 2018 - Elsevier
Introduction The prognosis of small-cell lung cancer (SCLC) is dismal and new effective
therapies are needed. Immunotherapy looks promising, but no molecular predictive markers …
被引用次数：115 相关文章 所有 6 个版本