The interaction of CD40 ligand (CD40L) on activated T cells with CD40 on B cells,
monocytes and dendritic cells is essential for humoral immunity and for up‐regulation of …

The cell surface molecule CD40 is a member of the tumor necrosis factor receptor (TNFR)
family and plays a pivotal role in the immune system due in part to its wide tissue …

CD40 plays a significant role in the pathogenesis of inflammation and autoimmunity. B cell
CD40 directly activates cells, which can result in autoantibody production. T cells can also …

CD40 is expressed on a diverse array of cell types from the hematopoeitic and non-
hematopoeitic compartments. Within the hematopoeitic compartment, CD40 is found …

Abstract The CD40–CD40 ligand (CD40L) system is of pivotal importance in the immune
response via interactions between T cells and antigen-presenting cells. Recent reports have …

▪ Abstract CD40-CD154–mediated contact-dependent signals between B and T cells are
required for the generation of thymus dependent (TD) humoral immune responses. CD40 …

The CD40 receptor is expressed constitutively on B lymphocytes, for which it provides
important signals regulating clonal expansion, antibody production and isotype switching, as …

▪ Abstract Over the past three years, CD40 and its ligand (gp39, CD40L, TBAM) have been
shown to be essential for humoral immune responses to thymus-dependent antigens …

Generation of an accurate humoral and a cell mediated adaptive immune responsesare
dictated by binding of an antigen to a T-and a B-cell receptor, respectively (first signal) …

CD40 was originally identified as a receptor on B-cells that delivers contact-dependent T
helper signals to B-cells through interaction with CD40 ligand (CD40L, CD154). The pivotal …