We have investigated the roles of TCR and accessory co-stimulatory signals in the induction
of CD40 ligand (CD40L) on CD4 cells. Using naive T cells from TCR transgenic mice …

ABSTRACT CD40 has emerged as a key signaling pathway for the function of B cells,
monocytes, and dendritic cells (DC) in the immune system, and plays a major role in …

Recent progress in the understanding of immune function indicates that the interaction of
CD40L with its receptor, CD40, plays a pivotal role in both humoral immunity and cell …

An engagement of CD40 with CD40 ligand (CD40L) expressed on activated T cells is known
to provide an essential costimulatory signal to B cells in vitro. To investigate the role of CD40 …

he study of T-cell activation re-mCCns an exciting endeavor, even though some of the
molecular details of T-cell activation have become apparent. A number of molecules …

Abstract The CD40: CD40 ligand (CD40L) interaction provides T lymphocyte‐mediated help
for B lymphocyte and monocyte function but has also been shown to serve as a co‐stimulus …

The CD40 receptor and its ligand CD40L is one of the most critical molecular pairs of the
stimulatory immune checkpoints. Both CD40 and CD40L have a membrane form and a …

This review focuses on the emerging body of literature suggesting a critical role for
CD40/CD154 interactions in antigen-presenting cell (APC) activation, CD4+ and CD8+ T …

Initially, a role for the interaction between CD40, expressed on B cells, and gp39 (CD40L),
expressed on activated T cells, has been defined in humoral immunity. CD40-CD40L …

The CD40 pathway plays a critical role at many levels of the sensitization and effector
phases of allograft rejection. In addition to the important signaling role of this pathway for T …