Regulation of cytoplasmic, surface and soluble forms of CD40 ligand in mouse B cells

M Wykes, J Poudrier, R Lindstedt… - European journal of …, 1998 - Wiley Online Library
Abstract CD40 and CD40 ligand (CD40L) form one of most important receptor‐ligand pairs
that dock during T‐B cell interactions as part of T‐dependent antibody responses. It has …

Signaling by CD40 and its mimics in B cell activation

GA Bishop, BS Hostager - Immunologic research, 2001 - Springer
CD40 is a member of the growing tumor necrosis factor receptor (TNF-R) family of molecules
and has been shown to play important roles in T cell-mediated B lymphocyte activation …

CD40 and autoimmunity: the dark side of a great activator

AL Peters, LL Stunz, GA Bishop - Seminars in immunology, 2009 - Elsevier
CD40 is a tumor necrosis factor receptor superfamily member expressed by immune and
non-immune cells. CD40: CD154 interactions mediate T-dependent B cell responses and …

The role of CD40-CD154 interaction in cell immunoregulation

Y Xu, G Song - Journal of biomedical science, 2004 - karger.com
CD40, a member of the nerve growth factor/tumor necrosis factor receptor superfamily, and
its ligand, CD154, play essential roles in cell immune responses. The results of many …

[PDF][PDF] CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system

K Chen, J Huang, W Gong, L Zhang, P Yu, JM Wang - Cell Mol Immunol, 2006 - Citeseer
CD40 is a member of the tumor necrosis factor (TNF) receptor family that is expressed on the
surface of immune cells, including B cells, monocytes, and dendritic cells, as well as non …

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

S Shinde, Y Wu, Y Guo, Q Niu, J Xu… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
Abstract The CD40 ligand (CD40L): CD40 interaction plays an important role in the
activation of both T and B cells. However, the mechanisms by which this interaction is …

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

MK Kennedy, KS Picha, WC Fanslow… - European journal of …, 1996 - Wiley Online Library
We have previously shown that T cell receptor‐activated mouse T helper (Th) 1 clones
induce the production of interleukin (IL)‐12 by splenic antigen‐presenting cells (APC). Here …

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

Y Guo, Y Wu, S Shinde, MS Sy, A Aruffo… - The Journal of …, 1996 - rupress.org
The interaction between CD40 ligand and CD40 is critical for activation of T and B cells in
vivo. We have recently demonstrated that this interaction rapidly induces a novel …

CD154 (CD40 ligand)

U Schönbeck, F Mach, P Libby - The international journal of biochemistry & …, 2000 - Elsevier
CD40 ligand, a type II transmembrane protein recently renamed CD154, was originally
considered restricted to activated T lymphocytes, functioning as a mediator of T cell …

The role of the CD40 pathway in the pathogenesis and treatment of cancer

AG Eliopoulos, LS Young - Current opinion in pharmacology, 2004 - Elsevier
CD40 is a tumour necrosis factor receptor family member that is overexpressed in a broad
range of leukaemias, lymphomas and carcinomas, and could contribute to their …