Antitumor effect of CD40 ligand: elicitation of local and systemic antitumor responses by IL-12 and B7
A Nakajima, T Kodama, S Morimoto… - The Journal of …, 1998 - journals.aai.org
The interaction between CD40 ligand (CD40L, CD154) and its receptor CD40 has been
implicated in the establishment of cell-mediated immunity as well as humoral immune …
implicated in the establishment of cell-mediated immunity as well as humoral immune …
B7/CD28-dependent and-independent induction of CD40 ligand expression.
L Ding, JM Green, CB Thompson… - Journal of immunology …, 1995 - journals.aai.org
The induction of a T cell-dependent Ab response is mediated by the interaction of the T cell
activation Ag, CD40 ligand (CD40L), with CD40. Since this interaction is independent of Ag …
activation Ag, CD40 ligand (CD40L), with CD40. Since this interaction is independent of Ag …
CD40-CD40 ligand-independent activation of CD8+ T cells can trigger allograft rejection
ND Jones, A Van Maurik, M Hara… - The Journal of …, 2000 - journals.aai.org
In experimental transplantation, blockade of CD40-CD40 ligand (CD40L) interactions has
proved effective at permitting long-term graft survival and has recently been approved for …
proved effective at permitting long-term graft survival and has recently been approved for …
Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease
HJ Gruss, D Hirschstein, B Wright, D Ulrich… - 1994 - ashpublications.org
CD40 was originally described as a B-cell-restricted antigen and was subsequently found to
be a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 is also …
be a member of the tumor necrosis factor (TNF) receptor superfamily. CD40 is also …
Role of CD27/CD70 pathway of activation in immunity and tolerance
J Denoeud, M Moser - Journal of leukocyte biology, 2011 - academic.oup.com
The CD70/CD27 axis has gained increasing interest among the immunologists, because of
its capacity to regulate immunity versus tolerance. Recent studies clearly show that …
its capacity to regulate immunity versus tolerance. Recent studies clearly show that …
CD40/CD154 interactions at the interface of tolerance and immunity
SA Quezada, LZ Jarvinen, EF Lind… - Annu. Rev. Immunol …, 2004 - annualreviews.org
Development of the acquired immune response is dependent on the signaling of CD40 by
its ligand, CD154. These molecules govern both the magnitude and quality of humoral-and …
its ligand, CD154. These molecules govern both the magnitude and quality of humoral-and …
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.
P Borrow, A Tishon, S Lee, J Xu, IS Grewal… - The Journal of …, 1996 - rupress.org
The ligand for CD40 (CD40L) is expressed on the surface of activated CD4+ T cells and its
role in TB cell collaborations and thymus-dependent humoral immunity is well established …
role in TB cell collaborations and thymus-dependent humoral immunity is well established …
Mice deficient for the CD40 ligand
J Xu, TM Foy, JD Laman, EA Elliott, JJ Dunn… - Immunity, 1994 - cell.com
To study the potential roles of CD40L in immune responses, we generated CD40L-deflcient
mice by gene targeting. Similar to the effecta of CD4OL mutations in humans (hype+ IgM …
mice by gene targeting. Similar to the effecta of CD4OL mutations in humans (hype+ IgM …
Analysis of the oligomeric requirement for signaling by CD40 using soluble multimeric forms of its ligand, CD154
LE Haswell, MJ Glennie… - European journal of …, 2001 - Wiley Online Library
We describe the construction of a novel soluble dodecameric form of CD154 (CD40 ligand)
that is more effective than trimeric tCD154 in triggering B cell activation. Dodecameric …
that is more effective than trimeric tCD154 in triggering B cell activation. Dodecameric …