Genetic manipulation in mice often combined with models of human disease has allowed
investigators to dissect specific disease pathways. These tools have taught us much about …

Animal models play an important role in the understanding of the pathogenesis of chronic
obstructive pulmonary disease (COPD). The applicability of findings to human COPD …

Over the past decade there has been a significant shift to the use of murine models for
investigations into the molecular basis of respiratory diseases, including asthma and chronic …

A variety of animal models of chronic obstructive pulmonary disease (COPD) are available,
comprising elastase instillation or inhalation of noxious agents and genetic models like …

Chronic obstructive pulmonary disease (COPD) is a major global health problem and is
predicted to become the third most common cause of death by 2020. Apart from the …

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation, that is
not fully reversible, and that is associated with an abnormal inflammatory response of the …

Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death in the UK,
1 causing 26 000 deaths and 240 000 hospital admissions and costing the NHS£ 486 …

Respiratory disorders like asthma, emphysema, and pulmonary fibrosis affect millions of
Americans and many more worldwide. Despite advancements in medical research that have …

Animal models of disease serve a vital function in the search for novel therapeutic
approaches. While these systems cannot replicate human disease, they can be used to …

The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD)
are poorly defined. This area is complicated and difficult to model because COPD consists of …