Purpose. This study assesses the impact of rat multidrug resistance-associated protein 2
(Mrp2) on the biliary excretion and oral absorption of furosemide, probenecid, and …

Abstract Background and Aim: Eisai hyperbilirubinuria rats (EHBR) are animal models of
Dubin–Johnson syndrome, which suffer from jaundice due to impaired biliary excretion of …

Phenobarbital (PB) treatment impairs the biliary excretion of some organic anions. One
mechanism may involve direct competition for biliary excretion by PB and/or a PB …

The function of multidrug resistance-associated protein 2 (Mrp2) in the intestine and liver, as
well as intestinal Mrp2 expression, was analyzed in CCl4-induced acute hepatic failure rats …

Purpose. It has been shown that plasma concentration and urinary excretion of bile acids is
elevated under the cholestatic/hyperbilirubinemic conditions. Previously, it was …

Regulation of bilirubin glucuronide transporters during hyperbilirubinemia in hepatic and
extrahepatic tissues is not completely clear. In the present study, we evaluated the …

No Heading Purpose. Multidrug resistance-associated protein 2 (MRP2/ABCC2) is
predominantly expressed in the liver canalicular membrane and plays an important role in …

We investigated whether the species difference in the biliary excretion activity of some Mrp2
substrates was attributable to the intrinsic transport potential or the expression level of Mrp2 …

1. The roles of multidrug resistance-associated protein (Mrp) 2 deficiency and Mrp3 up-
regulation were evaluated on the metabolism and disposition of gemfibrozil. 2. Results from …

The multidrug resistance protein Mrp2 is an ATP-binding cassette (ABC) transporter mainly
expressed in liver, kidney, and intestine. One of the physiological roles of Mrp2 is to …