[HTML][HTML] Targeting FAK in human cancer: from finding to first clinical trials

VM Golubovskaya - Frontiers in bioscience (Landmark edition), 2014 - ncbi.nlm.nih.gov
It is twenty years since Focal Adhesion Kinase (FAK) was found to be overexpressed in
many types of human cancer. FAK plays an important role in adhesion, spreading, motility …

Emerging roles of focal adhesion kinase in cancer

YL Tai, LC Chen, TL Shen - BioMed research international, 2015 - Wiley Online Library
Focal adhesion kinase (FAK) is a cytoplasmic nonreceptor tyrosine kinase that enables
activation by growth factor receptors or integrins in various types of human cancers. The …

FAK signaling in human cancer as a target for therapeutics

BY Lee, P Timpson, LG Horvath, RJ Daly - Pharmacology & therapeutics, 2015 - Elsevier
Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

FAK in cancer: from mechanisms to therapeutic strategies

HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights

H Yoon, JP Dehart, JM Murphy… - … of Histochemistry & …, 2015 - journals.sagepub.com
Focal adhesion kinase (FAK) is a protein tyrosine kinase that regulates cellular adhesion,
motility, proliferation and survival in various types of cells. Interestingly, FAK is activated …

Signal transduction by focal adhesion kinase in cancer

J Zhao, JL Guan - Cancer and Metastasis Reviews, 2009 - Springer
Cellular interactions with extracellular matrix play essential roles in tumor initiation,
progression and metastasis. Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase …

Functional and clinical characteristics of focal adhesion kinases in cancer progression

Z Zhang, J Li, S Jiao, G Han, J Zhu… - Frontiers in Cell and …, 2022 - frontiersin.org
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

[PDF][PDF] Focal adhesion kinase in cancer

TP Hecker, CL Gladson - Front Biosci, 2003 - article.imrpress.com
Focal adhesion kinase (FAK) is a non-receptor cytoplasmic tyrosine kinase that transmits
signals important in modulating several cell functions, including proliferation, migration, and …

Focal adhesion kinase as a potential target in oncology

GW McLean, E Avizienyte… - Expert opinion on …, 2003 - Taylor & Francis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays a pivotal role in
signal transduction at integrin-linked cellular adhesions, which mediate cell contact with the …