High‐titer biosynthesis of hyaluronic acid by recombinant Corynebacterium glutamicum

F Cheng, Q Gong, H Yu… - Biotechnology …, 2016 - Wiley Online Library
Hyaluronic acid (HA) plays important roles in human tissue system, thus it is highly desirable
for various applications, such as in medical, clinic and cosmetic fields. The wild microbial …

Enhanced Biosynthesis of Hyaluronic Acid Using Engineered Corynebacterium glutamicum Via Metabolic Pathway Regulation

F Cheng, S Luozhong, Z Guo, H Yu… - Biotechnology …, 2017 - Wiley Online Library
Hyaluronic acid (HA) is a polysaccharide used in many industries such as medicine,
surgery, cosmetics, and food. To avoid potential pathogenicity caused by its native producer …

Engineering Corynebacterium glutamicum for high-titer biosynthesis of hyaluronic acid

F Cheng, H Yu, G Stephanopoulos - Metabolic engineering, 2019 - Elsevier
Hyaluronic acid (HA) is a member of the glycosaminoglycan family and has been widely
used in the clinical, medical, cosmetic and food industries. In this study, we constructed a …

Hyaluronic acid production with Corynebacterium glutamicum: effect of media composition on yield and molecular weight

J Hoffmann, J Altenbuchner - Journal of applied microbiology, 2014 - academic.oup.com
Aims Corynebacterium glutamicum was tested as an alternative host for heterologous
production of hyaluronic acid (HA). Methods and Results A set of expression vectors …

Exploiting the diversity of streptococcal hyaluronan synthases for the production of molecular weight–tailored hyaluronan

S Schulte, SS Doss, P Jeeva, M Ananth… - Applied microbiology …, 2019 - Springer
The molecular weight (Mw) of hyaluronic acid (HA) determines its suitability for medical and
cosmetic applications. Here, we characterize in vitro and in vivo HA synthesis of …

Biotechnological production of hyaluronic acid: a mini review

JH Sze, JC Brownlie, CA Love - 3 Biotech, 2016 - Springer
Hyaluronic acid (HA) is a polysaccharide found in the extracellular matrix of vertebrate
epithelial, neural and connective tissues. Due to the high moisture retention, biocompatibility …

Versatile strategies for bioproduction of hyaluronic acid driven by synthetic biology

ZY Yao, J Qin, JS Gong, YH Ye, JY Qian, H Li… - Carbohydrate …, 2021 - Elsevier
Owing to its outstanding water-retention ability, viscoelasticity, biocompatibility and non-
immunogenicity, Hyaluronic acid (HA), a natural linear polymer alternating linked by d …

Recombinant Synthesis of Hyaluronan by Agrobacterium sp.

Z Mao, RR Chen - Biotechnology progress, 2007 - Wiley Online Library
Hyaluronan (HA) is a sugar polymer of a repeating disaccharide, β1–3 d‐N‐
acetylglucosamine (GlcNAc) β1–4 d‐glucuronic acid (GlcA). It finds applications in …

Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid

H Yu, G Stephanopoulos - Metabolic engineering, 2008 - Elsevier
Engineering of hyaluronic acid (HA) biosynthetic pathway in recombinant Escherichia coli as
production host is reported in this work. A hyaluronic acid synthase (HAS) gene, sphasA …

[HTML][HTML] Prospective bacterial and fungal sources of hyaluronic acid: A review

EV Shikina, RA Kovalevsky, AI Shirkovskaya… - Computational and …, 2022 - Elsevier
The unique biological and rheological properties make hyaluronic acid a sought-after
material for medicine and cosmetology. Due to very high purity requirements for hyaluronic …