Gene–environment interactions in psychiatry: joining forces with neuroscience

A Caspi, TE Moffitt - Nature Reviews Neuroscience, 2006 - nature.com
Gene–environment interaction research in psychiatry is new, and is a natural ally of
neuroscience. Mental disorders have known environmental causes, but there is …

Measured gene-environment interactions in psychopathology: Concepts, research strategies, and implications for research, intervention, and public understanding of …

TE Moffitt, A Caspi, M Rutter - Perspectives on Psychological …, 2006 - journals.sagepub.com
There is much curiosity about interactions between genes and environmental risk factors for
psychopathology, but this interest is accompanied by uncertainty. This article aims to …

Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search

R Uher - Social psychiatry and psychiatric epidemiology, 2014 - Springer
A decade of research has demonstrated the explanatory potential of interplay between
genetic variants and environmental factors in the development of common mental disorders …

Gene-environment interactions in psychiatry: recent evidence and clinical implications

RJ Musci, JL Augustinavicius, H Volk - Current psychiatry reports, 2019 - Springer
Abstract Purpose of Review We identify the recent evidence for gene-by-environment
interaction studies in relation to psychiatric disorders. We focus on the key genotypic data as …

Gene–environment interplay and psychopathology: Multiple varieties but real effects

M Rutter, TE Moffitt, A Caspi - Journal of child Psychology and …, 2006 - Wiley Online Library
Gene–environment interplay is a general term that covers several divergent concepts with
different meanings and different implications. In this review, we evaluate research evidence …

Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness

R Uher, A Zwicker - World Psychiatry, 2017 - Wiley Online Library
Intriguing findings on genetic and environmental causation suggest a need to reframe the
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …

Gene-environment interaction and psychiatric disorders: Review and future directions

E Assary, JP Vincent, R Keers, M Pluess - Seminars in cell & …, 2018 - Elsevier
Empirical studies suggest that psychiatric disorders result from a complex interplay between
genetic and environmental factors. Most evidence for such gene-environment interaction …

Gene–environment correlations: A review of the evidence and implications for prevention of mental illness

SR Jaffee, TS Price - Molecular psychiatry, 2007 - nature.com
Family studies have demonstrated genetic influences on environmental exposure: the
phenomenon of gene–environment correlation (rGE). A few molecular genetic studies have …

[HTML][HTML] Gene-environment interaction in evolutionary perspective: differential susceptibility to environmental influences

J Belsky, S Hartman - World Psychiatry, 2014 - ncbi.nlm.nih.gov
By tradition, psychiatrists have been concerned with the nature, origins, sequelae and
treatment of mental disorders. When it comes to etiology and the role of genetics, psychiatric …

Strategy for investigating interactions between measured genes and measured environments

TE Moffitt, A Caspi, M Rutter - Archives of general psychiatry, 2005 - jamanetwork.com
The purpose of this article is to promote research that tests hypotheses of measured gene-
environment interaction (GxE). A GxE occurs when the effect of exposure to an …