The immature plasmacytoid dendritic cell (PDC) is identical with the principal type I IFN‐
producing cell upon viral infection. Oligodeoxynucleotides which contain unmethylated CpG …

Two different CpG oligonucleotides (ODN) were used to study the regulation of type I IFN in
human plasmacytoid dendritic cells (PDC): ODN 2216, a CpG-A ODN, known to induce high …

Human plasmacytoid or CD4+ CD11c− type 2 dendritic cell precursors (PDC) were
identified as natural type I interferon (IFN)-producing cells in response to viral and bacterial …

Two different types of CpG motif‐containing oligonucleotides (CpG ODN) have been
described: CpG‐A with high induction of IFN‐α in plasmacytoid dendritic cells; and CpG‐B …

Two distinct types of CpG oligodeoxynucleotide (ODN) have been identified that differ in
their capacity to stimulate antigen-presenting cells: CpG-A induces high amounts of …

Two classes of nucleic acids, bacterial DNA containing unmethylated CpG motifs and
dsRNA in viruses, induce the production of type I IFN that contributes to the …

Dendritic cells (DC) excel at presenting antigen to T cells and thus make a key contribution
to the induction of primary and secondary immune responses. DC matured in vitro and …

Recent reports have identified two major classes of CpG motif-containing
oligodeoxynucleotide immunostimulatory sequences (ISS): uniformly modified …

Plasmacytoid dendritic cells (pDCs) respond to unmethylated cytosine-phosphate-
guanosine (CpG) motifs present in bacterial DNA or unmethylated synthetic …

Unmethylated CpG motifs in bacterial DNA or synthetic oligodeoxynucleotides (ODN) are
known for inducing a Th1 cytokine/chemokine environment, but the mechanisms regulating …