Molecular basis of functional diversity of voltage‐gated potassium channels in mammalian brain.

W Stühmer, JP Ruppersberg, KH Schröter… - The EMBO …, 1989 - embopress.org
Cloning and sequencing of cDNAs isolated from a rat cortex cDNA library reveals that a
gene family encodes several highly homologous K+ channel forming (RCK) proteins …

Heteromultimeric channels formed by rat brain potassium-channel proteins

JP Ruppersberg, KH Schröter, B Sakmann, M Stocker… - Nature, 1990 - nature.com
AN important step towards understanding the molecular basis of the functional diversity of
voltage-gated K+ channels in the mammalian brain has been the discovery of a family of …

Cloning and expression of a human voltage‐gated potassium channel. A novel member of the RCK potassium channel family.

A Grupe, KH Schröter, JP Ruppersberg… - The EMBO …, 1990 - embopress.org
We have isolated and characterized a human cDNA (HBK2) that is homologous to novel
member (RCK2) of the K+ channel RCK gene family expressed in rat brain. RCK2 mRNA …

Cloning and tissue-specific expression of five voltage-gated potassium channel cDNAs expressed in rat heart.

SL Roberds, MM Tamkun - Proceedings of the National …, 1991 - National Acad Sciences
Five distinct K+ channel cDNA molecules (RK1 to RK5) were cloned from either rat heart or
rat aorta cDNA libraries. Four of the channels, RK1 to RK4, are similar or identical to Shaker …

Heterogeneous expression patterns of mammalian potassium channel genes in developing and adult rat brain

WA Kues, F Wunder - European Journal of Neuroscience, 1992 - Wiley Online Library
Voltage‐gated K+ channels in the mammalian brain are functionally heterogeneous.
Mechanisms which may underlie heterogeneity are the expression of multiple K+ channel …

Characterization of a mammalian cDNA for an inactivating voltage-sensitive K+ channel

TJ Baldwin, ML Tsaur, GA Lopez, YN Jan, LY Jan - Neuron, 1991 - cell.com
A cDNA clone encoding a K+ channel polypeptide with 72% amino acid sequence identity to
Drosophila Shd was isolated from rat hippocampus. Functional expression of thecDNA in …

Images of purified Shaker potassium channels

M Li, N Unwin, KA Stauffer, YN Jan, LY Jan - Current Biology, 1994 - cell.com
Background: Voltage-gated K+ channels play an important role in the control of neuronal
excitability and synaptic plasticity. Their low abundance and extraordinary heterogeneity …

Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library

JCL Tseng-Crank, GN Tseng, A Schwartz, MA Tanouye - FEBS letters, 1990 - Elsevier
A full-length K+ channel cDNA (RHK1) was isolated from a rat cardiac library using the
polymerase chain reaction (PCR) method and degenerate oligonucleotide primers derived …

A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization

PM Hwang, CE Glatt, DS Bredt, G Yellen, SH Snyder - Neuron, 1992 - cell.com
Using a cDNA library prepared from circumvallate papillae of rat tongue, we have identified,
cloned, and sequenced a novel K+ channel, designated cdrk. The cdrk channel appears to …

How might the diversity of potassium channels be generated?

LY Jan, YN Jan - Trends in neurosciences, 1990 - cell.com
Potassium channels are a diverse group of ion channels present in most eukaryotic cells
that have been examined 1~ 3. Over 30 different potassium channels have been …