Prior lung inflammation impacts on body distribution of gold nanoparticles

S Hussain, JAJ Vanoirbeek, S Haenen… - BioMed research …, 2013 - Wiley Online Library
Introduction. Gold‐(Au‐) based nanomaterials have shown promising potential in
nanomedicine. The individual health status is an important determinant of the response to …

Inflammatory changes in lung tissues associated with altered inflammation-related microRNA expression after intravenous administration of gold nanoparticles in vivo

CT Ng, JEJ Li, SK Balasubramanian… - ACS Biomaterials …, 2016 - ACS Publications
Potential adverse effects of gold nanoparticles (AuNPs) are gaining attention due to their
wide industrial, consumer, and biomedical applications. This may give rise to possible …

Biodistribution of gold nanoparticles in mouse lung following intratracheal instillation

E Sadauskas, NR Jacobsen, G Danscher… - Chemistry Central …, 2009 - Springer
Background The fate of gold nanoparticles, 2, 40 and 100 nm, administered intratracheally
to adult female mice was examined. The nanoparticles were traced by autometallography …

Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

M Geiser, O Quaile, A Wenk, C Wigge… - Particle and fibre …, 2013 - Springer
Background Inhalative nanocarriers for local or systemic therapy are promising. Gold
nanoparticles (AuNP) have been widely considered as candidate material. Knowledge …

Distribution of polymer-coated gold nanoparticles in a 3D lung model and indication of apoptosis after repeated exposure

S Chortarea, K Fytianos, L Rodriguez-Lorenzo… - …, 2018 - Taylor & Francis
Aim: The distribution and impact of aerosol-delivered gold nanoparticles (AuNPs)
functionalized with a mixture of aminated-polyvinyl alcohol and amino-PEG ([polyvinyl …

Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages

S Takenaka, W Möller, M Semmler-Behnke, E Karg… - …, 2012 - Taylor & Francis
Aim: To investigate the relationship of alveolar macrophages and inhaled nanoparticles
(NPs) in the lung. Materials & methods: Rats were exposed by inhalation to 16-nm gold NPs …

Gold nanoparticles dissolve extracellularly in the presence of human macrophages

S McCarrick, K Midander, M Krausová… - International Journal …, 2021 - Taylor & Francis
Introduction Gold nanoparticles (AuNPs) have the potential to be used in various biomedical
applications, partly due to the inertness and stability of gold. Upon intravenous injection, the …

[HTML][HTML] Pulmonary fate and consequences of transferrin-functionalized gold nanoparticles

NV Konduru, K Velasco-Alzate, S Adduri… - …, 2021 - ncbi.nlm.nih.gov
Surface functionalization of nanoparticles (NPs) may alter their biological interactions such
as uptake by alveolar macrophages (AMs). Pulmonary delivery of gold NPs (Au NPs) has …

Translocation and effects of gold nanoparticles after inhalation exposure in rats

LE Yu, LY Lanry Yung, CN Ong, YL Tan… - …, 2007 - Taylor & Francis
This study was carried out to test the hypothesis that nanogold particles can accumulate in
the olfactory bulb, and translocate from the lung to other organs after inhalation exposure …

Effects and uptake of gold nanoparticles deposited at the air–liquid interface of a human epithelial airway model

C Brandenberger, B Rothen-Rutishauser… - Toxicology and applied …, 2010 - Elsevier
The impact of nanoparticles (NPs) in medicine and biology has increased rapidly in recent
years. Gold NPs have advantageous properties such as chemical stability, high electron …