Antibacterial research has evolved dramatically over the past five decades. Early work relied
on serendipity of finding drug-like molecules, usually natural products that had desirable …

Despite the ever-growing antibiotic resistance crisis, the rate at which new antimicrobials are
being discovered and approved for human use has rapidly declined over the past 75 years …

Sequencing of bacterial genomes has been progressing with breathtaking speed. Currently,
the genomes of 23 bacterial species are sequenced, with approximately 40 more …

Utilizing genome sequence data from bacterial and fungal pathogens for the discovery of
new antimicrobial agents has received considerable attention, both practical and critical …

Highlights•Multidrug resistant bacterial pathogens may compromise the clinical utility of
antimicrobial agents.•Certain pathogenic bacteria have developed several classes of …

Background Bacterial respiratory tract infections, mainly caused by Streptococcus
pneumoniae, Haemophilus influenzae and Moraxella catarrhalis are among the leading …

In the last two decades, the search for completely novel antibacterial agents has acquired a
new sense of urgency due to the remarkable rise of antibiotic resistance among key …

The dramatic rise in microbial drug resistance in recent years has led to ongoing searches
for novel drugs to add to the armory against infectious disease. Nevertheless, a paucity of …

Given the increase in antibiotic-resistant bacteria, alongside the alarmingly low rate of newly
approved antibiotics for clinical usage, we are on the verge of not having effective treatments …

Highlights•The threat of growing antimicrobial resistance urgently requires new 'silver
bullets'.•Traditional approaches to antibiotic discovery are failing to produce new antibiotics.• …