The importance of the human microbiome in health may be the single most valuable
development in our conception of the microbial world since Pasteur's germ theory of the …

Abstract The Community for Open Antimicrobial Drug Discovery aims to tap into the potential
of the millions of compounds distributed around laboratories globally to be a source of new …

Pandemic, epidemic and endemic infectious diseases are united by a common problem:
how do we rapidly and cost-effectively identify potential pharmacological interventions to …

The alarming rise in the emergence of antimicrobial resistance in human, animal and plant
pathogens is challenging global health and food production. Traditional strategies used for …

The appearance of antibiotic resistant pathogens, including vancomycin resistant
Staphylococcus aureus, in the clinic has necessitated the development of new antibiotics …

The widespread emergence of antibiotic-resistant pathogens poses a severe threat to public
health. This problem becomes even worse with a coincident decline in the supply of new …

The shrinking antibiotic development pipeline together with the global increase in antibiotic
resistant infections requires that new molecules with antimicrobial activity are developed …

We describe an ultra‐high‐throughput screening platform enabling discovery and/or
engineering of natural product antibiotics. The methodology involves creation of hydrogel‐in …

Databases and chemo-and bioinformatics tools that contain genomic, proteomic and
functional information have become indispensable for antimicrobial drug research. The …

Available genomic data for pathogens has created new opportunities for drug discovery and
development to fight them, including new resistant and multiresistant strains. In particular …