Previous studies of patients with Alzheimer's disease (AD) have described reduced brain
serotonin 2A (5-HT2A) receptor density. It is unclear whether this abnormality sets in early in …

We previously demonstrated a 20–30% reduction in cortical 5-HT2A receptor binding in
patients with mild cognitive impairment (MCI) as compared to healthy subjects. Here we …

In patients with Alzheimer's disease (AD), postmortem and imaging studies have revealed
early and prominent reductions in cerebral serotonin 2A (5-HT2A) receptors. To establish if …

Postmortem studies show reductions in brain serotonin 2A (5-HT2A) receptors in
Alzheimer's disease (AD). Converging evidence also suggests that serotonergic …

Objective The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT 1A]) receptors
in cognition, behavior, and drug response is increasingly being recognized. Postmortem …

Rationale Previous studies have demonstrated reductions of serotonin 5-HT 2A receptors in
the neocortex of Alzheimer's disease (AD) patients. However, it is unclear whether such …

Objective: Recent studies have suggested modifications of serotonin cerebral metabolism
and of 5-HT1A receptors density in Alzheimer disease (AD). This study aims at exploring …

The 5-HT 4 receptor may play a role in memory and learning and 5-HT 4 receptor activation
has been suggested to modulate acetylcholine release and to reduce amyloid-β (Aβ) …

Serotonin (5-HT) and more specifically the 5-HT2A receptor is involved in cognitive and non-
cognitive behavior and plays an important role in Alzheimer's disease (AD). The objective …

Previous studies have implicated brain serotonin 5-HT1A receptors in several CNS
functions, including cognition, mood and emotional states. In Alzheimer disease (AD) …