Kidneys are highly complex organs, playing a crucial role in human physiopathology, as
they are implicated in vital processes, such as fluid filtration and vasomotor tone regulation …

Homeostasis relies on the intimate interplay between extracellular, intracellular and
intercellular signaling networks. Direct communication between adjacent cells is mediated …

Control of blood flow distribution and tissue homeostasis depend on the tight regulation of
and coordination between the microvascular network and circulating blood cells. Channels …

Functional interaction between neurons and glia is an exciting field that has expanded
tremendously during the past decade. Such partnership has multiple impacts on neuronal …

Gap junctions (GJ) and hemichannels (HC) formed from the protein subunits called
connexins are transmembrane conduits for the exchange of small molecules and ions …

Connexin hemichannels are single membrane channels which have been traditionally
thought to work in pairs to form gap junction channels across two opposing cells. In …

The occurrence of intercellular channels formed by pannexin1 has been challenged for
more than a decade. Here, we provide an electrophysiological characterization of …

Coordinated interaction among cells is critical to develop the extremely complex and
dynamic tasks performed by the central nervous system (CNS). Cell synchronization is in …

While gap junctions support the exchange of a number of molecules between neighboring
cells, connexin hemichannels provide communication between the cytosol and the …

Pannexins have been proposed to play a role in gap junctional intercellular communication
and as single-membrane channels, although many of their molecular characteristics differ …