The molecular identity of the protein forming “hemichannels” at non-junctional membranes is
disputed. The family of gap junction proteins, innexins, connexins, and pannexins share …

Pannexins are a family of glycoproteins that comprises three members, PANX1, PANX2, and
PANX3. The widely expressed and interrogated PANX1 forms heptameric membrane …

Abstract Connexin (Cx) and pannexin (Panx) containing channels–gap junctions (GJs) and
hemichannels (HCs)–are present in virtually all cells and tissues. Currently, the role of these …

The pannexin family of mammalian proteins, composed of Panx1, Panx2, and Panx3, has
been postulated to be a new class of single-membrane channels with functional similarities …

Gap-junction-dependent neuronal communication is widespread in the developing brain,
and the prevalence of gap-junctional coupling is well correlated with specific developmental …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …

Gap junction hemichannels and cell–cell channels have roles in coordinating numerous
cellular processes, due to their permeability to extra and intracellular signaling molecules …

Vertebrates express two families of gap junction proteins: the well characterized connexins
and the recently discovered pannexins. The latter are related to invertebrate innexins. Here …

Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity.
Pannexin channels have been suggested to participate in a wide spectrum of biological …

Gap junctions allow the exchange of ions, second messengers, and small metabolites
between adjacent cells and are formed by two unrelated protein families, the pannexins and …