BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide
remarkable cellular platforms to better understand human hematopoiesis and to develop …

Induced pluripotent stem cells (iPSC) technology has propelled the field of stem cells
biology, providing new cells to explore the molecular mechanisms of pluripotency, cancer …

Basic experimental stem cell research has opened up the possibility of many diverse clinical
applications; however, translation to clinical trials has been restricted to only a few diseases …

Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged
cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing …

After years of incremental progress, several recent studies have succeeded in deriving
disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect …

The promise of human induced pluripotent stem cells (iPSCs) lies in their ability to serve as
a starting material for autologous, or patient‐specific, stem cell–based therapies. Since the …

In this issue of Cell Stem Cell, Staerk et al.(2010), Seki et al.(2010), and Loh et al.(2010)
each describe the derivation of human iPSCs from peripheral blood. Although seemingly …

Human pluripotent stem cells (hPSCs) have practically unlimited proliferation potential and a
capability to differentiate into any cell type in the human body. Since the first derivation in …

Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …