Mitochondrial DNA (mtDNA) point mutations are known to accumulate in an age-dependent
fashion in somatic tissues. This study investigated whether a point mutation (T414G) in the …

Mitochondrial DNA (mtDNA) of oocyte is critical for its function, embryo quality and
development. Analysis of complete mtDNA of 49 oocytes and 18 blastocysts from 67 females …

STUDY QUESTION Does ovarian ageing increase the number of heteroplasmic
mitochondrial DNA (mtDNA) point mutations in oocytes? SUMMARY ANSWER Our results …

Objective To determine whether oocytes from women harbor deletions in mitochondrial DNA
(mtDNA) and whether deleted mtDNA is more common in oocytes from older women than …

It is likely that there is an association between the fitness of mitochondria and their ability to
support normal cellular function. Oocytes are greatly enriched in the number of mitochondria …

Mitochondria are the largest generator of ATP in the cell. It is therefore expected that energy‐
requiring processes such as oocyte maturation, early embryonic or fetal development, would …

STUDY QUESTION What are the molecular differences between mitochondrial DNA
(mtDNA)-deficient and mtDNA-normal oocytes and how does mitochondrial …

Mitochondria play a fundamental role during development of the female germline. They are
fragmented, round, and small. Despite these characteristics suggesting that they are …

Objective: To determine the rearrangement of mitochondrial DNA (mtDNA) in unfertilized
human oocytes and compromised embryos to evaluate the fertilization capacity of oocytes …

Mitochondria are the most abundant organelles in mammalian oocytes and early embryos.
Mitochondrial DNA (mtDNA) mutations, including the common deletion, have been found in …