Performing drug screening of tissue derived from cancer patient biopsies using
physiologically relevant 3D tumour models presents challenges due to the limited amount of …

A recent decline in the discovery of novel medications challenges the widespread use of 2D
monolayer cell assays in the drug discovery process. As a result, the need for more …

Abstract Three-dimensional (3D) tumor spheroid possesses great potential as an in vitro
model to improve predictive capacity for pre-clinical drug testing. In this paper, we combine …

Despite monolayer cultures being widely used for cancer drug development and testing, 2D
cultures tend to be hypersensitive to chemotherapy and are relatively poor predictors of …

Spheroids present a biologically relevant three-dimensional model of avascular tumors and
a unique tool for discovery of anticancer drugs. Despite being used in research laboratories …

Drug resistance remains a major clinical problem despite advances in targeted therapies. In
recent years, methods to culture cancer cells in three-dimensional (3D) environments to …

Summary 3D in vitro cancer models are important therapeutic and biological discovery tools,
yet formation of matrix-embedded multicellular spheroids prepared in high-throughput …

Abstract Treatment following early diagnosis of Prostate cancer (PCa) is increasingly
successful, whilst the treatment of advanced and metastatic PCa remains challenging. A …

High attrition of new oncology drug candidates in clinical trials is partially caused by the poor
predictive capacity of artificial monolayer cell culture assays early in drug discovery …

Three-dimensional (3D) cell culture is considered more clinically relevant in mimicking the
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …