Abstract IFN regulatory factor (IRF)-1 and IRF-2 are generally regarded as a tumor
suppressor and an oncoprotein, respectively. However, little is known about their expression …

Background Hypoxia plays a critical role in many cancers. Hypoxia inducible factor-1α (HIF-
1α) is an important mediator of the hypoxia response. It regulates the expression of various …

Abnormal expression of insulin-like growth factor I receptor (IGF-IR) is associated with
hepatocellular carcinoma (HCC) progression with largely unknown mechanisms. In this …

Insulin‐like growth factor binding protein‐3 (IGFBP‐3) modulates cell proliferation of various
cancer cell types. However, it remains unclear how IGF–IGFBP‐3‐signaling is involved in …

IFN-γ is an antitumor cytokine that inhibits cell proliferation and induces apoptosis after
engagement with the IFN-γ receptors (IFNGR) expressed on target cells, whereas IFN …

Lung cancer, specifically non-small cell lung cancer (NSCLC), is the leading cause of
cancer‑associated mortality in the world. In previous years, almost no significant …

The transcription factor, interferon regulatory factor 4 (IRF4), serves an essential role in the
regulation of immune responses, and has been reported to act as a diagnostic and …

Objective Pancreatic cancer is one of the most malignant diseases worldwide. Interferon
regulatory factor (IRF) 1 and IRF2 function as a tumor suppressor and oncoprotein …

Abstract Background and Aims Therapeutic blockade of the programmed cell death protein‐
1 (PD‐1) immune checkpoint pathways has resulted in significant reactivation of T cell …

The aim of this study is to investigate the expression levels and clinical significance of ILF2
in gastric cancer. The mRNA and protein expression levels of ILF2 were, respectively …