Galanin impairs performance on learning and memory tasks: findings from galanin transgenic and GAL-R1 knockout mice

NR Rustay, CC Wrenn, JW Kinney, A Holmes… - Neuropeptides, 2005 - Elsevier
Galanin (GAL) impairs performance on cognitive tasks when administered centrally to rats.
GAL transgenic (GAL-tg) mice overexpressing endogenous GAL show deficits on the probe …

Galanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease

SE Counts, B He, S Che, SD Ginsberg… - Journal of Alzheimer's …, 2009 - content.iospress.com
Fibers containing galanin (GAL) hyperinnervate cholinergic basal forebrain (CBF) nucleus
basalis neurons in late stage Alzheimer's disease (AD), yet the molecular consequences of …

Galanin protects against intracellular amyloid toxicity in human primary neurons

J Cui, Q Chen, X Yue, X Jiang, GF Gao… - Journal of …, 2010 - content.iospress.com
Galanin and galanin receptors are upregulated in the brain regions associated with
Alzheimer's disease (AD). However, the consequence of this overexpression is still …

Galanin receptor over-expression within the amygdala in early Alzheimer's disease:: An in vitro autoradiographic analysis

S Pérez, M Basile, DC Mash, EJ Mufson - Journal of chemical …, 2002 - Elsevier
Galanin receptor (GALR) expression is increased in various areas of the limbic system in
end stage Alzheimer's disease (AD). The amygdaloid complex is a key component of the …

Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease

JN Crawley - Galanin, 2010 - Springer
The neuropeptide galanin and its receptors are localized in brain pathways that mediate
learning and memory. Central microinjection of galanin impairs performance of a variety of …

Galanin–25 years with a multitalented neuropeptide: Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's Disease

JN Crawley - Cellular and Molecular Life Sciences, 2008 - Springer
The neuropeptide galanin and its receptors are localized in brain pathways mediating
learning and memory. Central microinjection of galanin impairs performance of a variety of …

Galanin inhibits performance on rodent memory tasks

MP McDONALD, TC Gleason… - Annals of the New …, 1998 - Wiley Online Library
Central administration of galanin produces performance deficits on a variety of rodent
learning and memory tasks. Galanin impairs acquisition and/or retention of the Morris water …

Involvement of neuropeptide galanin receptors 2 and 3 in learning, memory and anxiety in aging mice

F Locker, L Bieler, LMF Nowack, J Leitner, SM Brunner… - Molecules, 2021 - mdpi.com
The neuropeptide galanin (GAL), which is expressed in limbic brain structures, has a strong
impact on the regulation of mood and behavior. GAL exerts its effects via three G protein …

Long-term plastic changes in galanin innervation in the rat basal forebrain

I Hartonian, EJ Mufson, S De Lacalle - Neuroscience, 2002 - Elsevier
Galanin immunoreactive fibers hyperinnervate remaining cholinergic basal forebrain
neurons in Alzheimer's disease, perhaps exacerbating the cholinergic deficit. The purpose …

Galanin protects amyloid-β-induced neurotoxicity on primary cultured hippocampal neurons of rats

Y Cheng, LC Yu - journal of Alzheimer's Disease, 2010 - content.iospress.com
The neuropeptide galanin and its receptors are found to be upregulated in brain associated
with Alzheimer's disease (AD), while the role of galanin in AD is still unclear. The present …