Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: implications for its role in Alzheimer's disease
JH Jhamandas, KH Harris… - Journal of …, 2002 - journals.physiology.org
Galanin, a 29-amino-acid neuropeptide, is generally viewed as an inhibitory
neuromodulator in a variety of central systems. Galanin expression is upregulated in the …
neuromodulator in a variety of central systems. Galanin expression is upregulated in the …
A role for galanin in human and experimental inflammatory demyelination
DC Wraith, R Pope, H Butzkueven… - Proceedings of the …, 2009 - National Acad Sciences
The neuropeptide galanin is widely expressed by many differing subsets of neurons in the
nervous system. There is a marked upregulation in the levels of the peptide in a variety of …
nervous system. There is a marked upregulation in the levels of the peptide in a variety of …
Galanin acts as a trophic factor to the central and peripheral nervous systems
SA Hobson, A Bacon, CR Elliot-Hunt, FE Holmes… - Galanin, 2010 - Springer
The neuropeptide galanin is widely, but not ubiquitously, expressed in the adult nervous
system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury …
system. Its expression is markedly up-regulated in many neuronal tissues after nerve injury …
Galanin Expression within the Basal Forebrain in Alzheimer's Disease: Comments on Therapeutic Potentiala
The inhibitory neuropeptide galanin has widespread distribution throughout the central
nervous system. Studies indicate that galanin modulates cognition by regulating cholinergic …
nervous system. Studies indicate that galanin modulates cognition by regulating cholinergic …
Selective reduction in ventral hippocampal acetylcholine release in awake galanin-treated rats and galanin-overexpressing transgenic mice
F Laplante, JN Crawley, R Quirion - Regulatory peptides, 2004 - Elsevier
The neuropeptide galanin is an inhibitory modulator of hippocampal acetylcholine (ACh)
release and cognitive functions. Anatomical evidence demonstrated some differences …
release and cognitive functions. Anatomical evidence demonstrated some differences …
[HTML][HTML] Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice
PE Schauwecker - PLoS One, 2010 - journals.plos.org
Background Galanin is a neuropeptide with a wide distribution in the central and peripheral
nervous systems and whose physiological effects are mediated through three G protein …
nervous systems and whose physiological effects are mediated through three G protein …
Preservation of noradrenergic neurons in the locus ceruleus that coexpress galanin mRNA in Alzheimer's disease.
MA Miller, PE Kolb, JB Leverenz… - Journal of …, 1999 - search.ebscohost.com
Abstract: Galanin (GAL) innervation is hypertrophied in the basal forebrain and cortex of
patients with Alzheimer's disease (AD). Increased GAL could exacerbate the cognitive and …
patients with Alzheimer's disease (AD). Increased GAL could exacerbate the cognitive and …
[HTML][HTML] Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model
Multiple Sclerosis (MS) is a demyelinating autoimmune disease of the central nervous
system (CNS) with a presumed autoimmune etiology. Approved treatments for MS are …
system (CNS) with a presumed autoimmune etiology. Approved treatments for MS are …
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor
MM Gresle, H Butzkueven, VM Perreau, A Jonas… - Glia, 2015 - Wiley Online Library
In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC)
survival, we utilized microarrays to characterize changes in OC gene expression after …
survival, we utilized microarrays to characterize changes in OC gene expression after …
Galanin-acetylcholine interactions: relevance to memory and Alzheimer's disease
JN Crawley - Life sciences, 1996 - Elsevier
The neuropeptide, galanin, and its receptors are localized in the cholinergic basal forebrain
and its projection areas in mammalian brain. Centrally administered galanin inhibits …
and its projection areas in mammalian brain. Centrally administered galanin inhibits …