Expression and plasticity of galanin systems in cortical neurons, oligodendrocyte progenitors and proliferative zones in normal brain and after spreading depression

PJ Shen, JA Larm, AL Gundlach - European Journal of …, 2003 - Wiley Online Library
Neocortex contains very few galanin neurons but receives a moderate galanin innervation
from various subcortical loci. Recent data suggest that galanin helps regulate the tonic …

Elevated galanin may predict the risk of type 2 diabetes mellitus for development of Alzheimer's disease

Z Zhang, P Fang, M Shi, Y Zhu, P Bo - Mechanisms of Ageing and …, 2015 - Elsevier
Alzheimer's disease is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological and clinical …

Regulation of galanin in memory pathways

MA Miller - Annals of the New York Academy of Sciences, 1998 - Wiley Online Library
Based on early immunocytochemical findings, galanin (GAL) was postulated to function as
an inhibitory cotransmitter in rat cholinergic memory pathways. However, recent studies …

Modulation of hippocampal excitability and seizures by galanin

AM Mazarati, JG Hohmann, A Bacon, H Liu… - Journal of …, 2000 - Soc Neuroscience
Previous studies have shown that the expression of the neuropeptide galanin in the
hippocampus is altered by seizures and that exogenous administration of galanin into the …

Changes in brain cholinergic markers and spatial learning in old galanin-overexpressing mice

S Pirondi, G D'Intino, M Gusciglio, A Massella… - Brain research, 2007 - Elsevier
The cholinergic forebrain system is involved in learning and memory, and its age-dependent
decline correlates with a decrease in cognitive performance. Since the neuropeptide galanin …

Elimination of galanin synthesis in noradrenergic neurons reduces galanin in select brain areas and promotes active coping behaviors

RP Tillage, NR Sciolino, NW Plummer… - Brain Structure and …, 2020 - Springer
Accumulating evidence indicates that disruption of galanin signaling is associated with
neuropsychiatric disease, but the precise functions of this neuropeptide remain largely …

The brain galanin receptors: targets for novel antidepressant drugs

X Lu, L Sharkey, T Bartfai - CNS & Neurological Disorders …, 2007 - ingentaconnect.com
Our present view that the mood disorders involve dysfunction of monoaminergic system is a
result of important clinical and preclinical observations over the past 40 years. The …

Behavioral and neurochemical studies on brain aging in galanin overexpressing mice

S Pirondi, E Kuteeva, L Giardino, L Ferraro, T Antonelli… - Neuropeptides, 2005 - Elsevier
To study possible involvement of galanin in brain aging quality, we have investigated
behavioral, neurochemical and morphological parameters in aged mice overexpressing …

GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors

C Abbosh, A Lawkowski, M Zaben… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 117, 425–436. Abstract Understanding how neural activity is
functionally linked to the stem cell niche, is assuming ever increasing importance as …

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain

E Keimpema, K Zheng, SS Barde, P Berghuis… - Cerebral …, 2014 - academic.oup.com
The distribution and (patho-) physiological role of neuropeptides in the adult and aging brain
have been extensively studied. Galanin is an inhibitory neuropeptide that can coexist with γ …