The neuropeptide galanin (GAL) has been proposed to be an inhibitory modulator of
cholinergic transmission in the hippocampus and may impair memory by directly affecting …

Introduction Depletion of cholinergic neurons within the nucleus basalis of Meynert (nbM) is
thought to contribute to the development of cognitive impairments in both Alzheimer's …

Galanin is a modulator of fast transmission in adult brain and recent evidence suggests that
it also acts as a trophic factor during neurogenesis and neural injury and repair. Previous …

Galanin is a peptide that is associated with cholinergic neurons of the basal forebrain and,
thus, of interest for the neuropathology of Alzheimer's disease. In the present study, human …

Galanin-like immunoreactivity co-exists with choline acetyltransferaselike immunoreactivity
in neurons of the septal-hippocampal and nucleus basa/is of Meynert-neocortical pathways …

Galanin (GAL) is a potential target for novel antidepressant or anti-anxiety drug
development. However, no integrated role for a “brain galanin system” in anxiety has yet …

Age is a major risk factor for developing chronic diseases, including type 2 diabetes,
depression and Alzheimer's disease. The rapidly increase in the morbidity of these age …

Abstract [125 I] Galanin binding sites were examined in the hippocampal region of patients
with Alzheimer's disease (AD) and age-matched control subjects using quantitative …

Galanin is a widely-distributed neuropeptide that acts as an endogenous anticonvulsant. We
have recently generated a galanin receptor type 1 knockout mouse (Galr1−/−) that develops …

The pharmacological exploitation of the galanin receptors as drug targets for treatment of
epilepsy, depression, and pain has been hampered by the lack of workable compounds for …