The CXCR3 chemokine receptor was discovered in 1996 and has been shown to play an
important role in several diseases, most of which are related to inflammation. This chapter …

The CXCR3 chemokine receptor was first discovered in 1996 and has been shown to play
an important role in several diseases, most of which are related to inflammation. This review …

Chemokines and their receptors are known to play important roles in disease. More than 40
chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two …

CXCR3 is a CXC chemokine receptor that, together with its three major ligands, CXCL9
(MIG), CXCL10 (IP-10), and CXCL11 (I-TAC), is involved in inflammatory responses …

The chemokine receptor CXCR4 possesses multiple critical functions in normal and
pathologic physiology. CXCR4 is a G‐protein‐coupled receptor that transduces signals of its …

Dysregulated leukocyte recruitment is believed to be a key contributor to various acute and
chronic inflammatory disorders which can lead to serious pathological consequences …

Seven transmembrane (7TM) G-protein-coupled receptor (GPCR) families are important
targets for drug discovery, and specific antagonists for GPCR can accelerate research in the …

The chemokine receptors CXCR1 and CXCR2 are G-protein-coupled receptors (GPCRs)
implicated in mediating cellular functions associated with the inflammatory response. Potent …

The chemokine receptor CXCR2 is involved in different inflammatory diseases, like chronic
obstructive pulmonary disease, psoriasis, rheumatoid arthritis, and ulcerative colitis; …

Chemokine receptors are a target of growing interest for new therapeutic drugs, as their role
in multiple disease states has been demonstrated. The CXCR4/CXCL12 pairing has been …