Painful peripheral neuropathy is a common secondary complication of diabetes. The
streptozotocin (STZ)‐induced diabetic rat is the most commonly employed animal model …

Streptozotocin (STZ)-induced diabetes in the rat has been increasingly used as a model of
painful diabetic neuropathy to assess the efficacies of potential analgesic agents. We have …

Diabetic neuropathy is a common complication of diabetes. It occurs in approximately 10–
20% of patients with diabetes, or roughly 40–50% patients with diabetic neuropathy …

The procedures to induce insulin-deficient diabetes in rats using streptozotocin are
described along with a number of insulin treatment regimes that can be used to maintain …

Abnormal sensations and pain are features of approximately 10% of all cases of diabetic
neuropathy and can cause marked diminution in the quality of life for these patients. The …

Painful neuropathy is common in human diabetes. In rats, experimental diabetes results in
altered pain sensitivity. We examined the effect of chronic insulin treatment on diabetes …

Diabetes mellitus is one of the most rapidly growing health concerns in the developed world
due to the persistence of type 1 (insulin-deficient) diabetes and the dramatic increase in type …

Neuropathy will afflict over half of the approximately 350 million people worldwide who
currently suffer from diabetes and around one-third of diabetic patients with neuropathy will …

Pain is frequently the earliest and most problematic syndrome of distal peripheral
neuropathy (DPN) in diabetic patients. The variety of time of onset, duration and …

Diabetic peripheral neuropathy (DPN) is the most common clinical complication of diabetes
mellitus, and can be related to type 1 as well as type 2. To date, this highly invalidating …