Aspirin ingestion is a common precipitating factor of life-threatening asthma attacks,
requiring some patients to undergo mechanical ventilation. The gene, D-tyrosyl-tRNA …

Asthma is a respiratory disease caused by the interaction of genetic and environmental
factors. The adenylyl cyclase type 9 (ADCY9) enzyme produces the cyclic …

Background: Asthma is complex disease which pathogenesis is a mix of environmental and
genetic factors. A predisposition of airways to bronchoconstriction is one of main risk factors …

Background Aspirin-exacerbated respiratory disease (AERD) is an endotype of severe and
eosinophilic adult asthma characterized by chronic rhinosinusitis with nasal polyps and …

Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by
chronic rhinosinusitis with nasal polyposis and aspirin hypersensitivity. The aspirin-induced …

Aims: Cysteinyl leukotrienes are inactivated by acetyl coenzyme A-dependent N-
acetyltransferase (NAT). Thus, functional alterations of the NAT gene may contribute to the …

Short‐acting b2‐adrenergic receptor agonists are commonly used bronchodilators for
symptom relief in asthmatics. The aim of this study was to test whether genetic variants in …

Bronchial asthma (BA) is one of the most common respiratory system diseases. The role of
innate immunity components in the pathogenesis of bronchial asthma is studied widely, with …

In asthmatic airways, adenosine is a potent bronchoconstrictor with either pro-or anti-
inflammatory effects depending on receptor interactions. While aspirin has been suggested …

Background Two common clinical syndromes of acetylsalicylic acid (aspirin)
hypersensitivity, aspirin-exacerbated respiratory disease (AERD) and aspirin-exacerbated …