ADRB2 Arg16Gly polymorphism and pulmonary function response of inhaled corticosteroids plus long‐acting beta agonists for asthma treatment: a systematic review …

X Wang, Q Li, R Liu, J He, D Wu… - Canadian Respiratory …, 2018 - Wiley Online Library
Background. The beta‐2 adrenergic receptor (ADRB2) Arg16Gly polymorphism may alter
the bronchodilation response to long‐acting beta2‐agonists, thereby influencing the clinical …

Genetic impact of CDHR3 on the adult onset of asthma and COPD

R Shigemasa, H Masuko, K Hyodo… - Clinical & …, 2020 - Wiley Online Library
Background Adult‐onset asthma and chronic obstructive pulmonary disease (COPD) are
heterogeneous diseases caused by complex gene‐environment interactions. A functional …

Genetic heterogeneity of asthma phenotypes identified by a clustering approach

V Siroux, JR González, E Bouzigon… - European …, 2014 - Eur Respiratory Soc
The aim of the study was to identify genetic variants associated with refined asthma
phenotypes enabling multiple features of the disease to be taken into account. Latent class …

Autophagy‐related 5 gene mRNA expression and ATG5 rs510432 polymorphism in children with bronchial asthma

ES Ahmad, SM Diab, EG Behiry… - Pediatric …, 2022 - Wiley Online Library
Purpose Bronchial asthma is a common chronic respiratory disease in children with complex
pathogenesis, characterized by airway hyper‐responsiveness, obstruction, mucus …

[HTML][HTML] Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis

TA Olafsdottir, F Theodors, K Bjarnadottir… - Nature …, 2020 - nature.com
Asthma is one of the most common chronic diseases affecting both children and adults. We
report a genome-wide association meta-analysis of 69,189 cases and 702,199 controls from …

Polymorphisms in the DAD1 and OXA1L genes are associated with asthma and atopy in a South American population

A de Oliveira Pires, G de Almeida Queiroz… - Molecular …, 2018 - Elsevier
Atopic asthma, which is characterized by the chronic inflammation and morbidity of airways,
is a disease of great complexity, and multiple genetic and environmental factors are involved …

Asthma treatment response to inhaled corticosteroids is associated with variants in VEGFA gene

J Debeljak, P Korošec, A Lopert, M Fležar, M Košnik… - Gene, 2021 - Elsevier
Asthma is a common, chronic disease usually characterized by airway inflammation,
affecting 1–18% of the population worldwide (Initiative, 2020). Airway inflammation is …

[HTML][HTML] Pharmacogenetic factors affecting asthma treatment response. potential implications for drug therapy

JM García-Menaya, C Cordobés-Durán… - Frontiers in …, 2019 - frontiersin.org
Asthma is a frequent disease, mainly characterized by airway inflammation, in which drug
therapy is crucial in its management. The potential of pharmacogenomics testing in asthma …

Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions

X Li, TD Howard, SL Zheng, T Haselkorn… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Asthma is a heterogeneous disease that is caused by the interaction of
genetic susceptibility with environmental influences. Genome-wide association studies …

Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin

L Yang, I Lewkowich, K Apsley, JM Fritz… - The Journal of …, 2015 - journals.aai.org
Allergic asthma is a chronic inflammatory disorder that affects∼ 20% of the population
worldwide. Microarray analyses of nasal epithelial cells from acute asthmatic patients …