Abstract β-Lactamase inhibitors such as sulbactam are (β-lactam compounds that have low
antimicrobial activity but are able to inhibit enzymes (β-lactamases) that destroy j3-lactam …

We studied the efficacy of sulbactam, a beta-lactamase inhibitor, in combination with
ceftriaxone in vitro and in experimental endocarditis due to an Escherichia coli strain …

Three concentrations of the penicillanic acid sulfone, sulbactam were tested in combination
with cefoperazone against 632 recent clinical bacterial isolates. Cefoperazone was effective …

Sulbactam irreversibly inhibits the hydrolytic activity of β-lactamases. This compound is
commercially available in combination with either ampicillin or cefoperazone. In each …

Sulbactam, a class A β-lactamase inhibitor, added to cefoperazone either at a fixed 8 mg/L
level of sulbactam or at a level of fixed cefoperazone: sulbactam ratio (2: 1) would constitute …

beta-Lactamases constitute the major defense mechanism of pathogenic bacteria against
beta-lactam antibiotics. When the beta-lactam ring of this antibiotic class is hydrolyzed …

Cefoperazone, a cephalosporin which inhibits most Enterobacteriaceae, Pseudomonas
aeruginosa and Staphylococcus aureus, is hydrolyzed by some β-lactamases. Combination …

Cefoperazone was tested against 554 clinical isolates alone and with sulbactam in three
combinations. The addition of sulbactam in low concentrations (≤ 4 µg/ml) improved the …

The in vitro activity and β-lactamase stability of 7-[d (−)-α-(4-ethyl-2, 3-dioxopiperazino-
carbonylamino)-p-hydroxyphenylacetamido]-3-[(1-methyl)-5-tetrazolylthiomethyl]-Δ3 …

A wide variety of β-lactamases are found in clinical isolates of bacteria and, when present,
these enzymes often result in resistance to one or more β-lactam antibiotics. The prevalence …