The microRNA-455 null mouse has memory deficit and increased anxiety, targeting key genes involved in Alzheimer's disease
TE Swingler, L Niu, MG Pontifex, D Vauzour… - International journal of …, 2022 - mdpi.com
The complete molecular mechanisms underlying the pathophysiology of Alzheimer's
disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a …
disease (AD) remain to be elucidated. Recently, microRNA-455-3p has been identified as a …
miRNA-31 improves cognition and abolishes amyloid-β pathology by targeting APP and BACE1 in an animal model of Alzheimer's disease
AT Barros-Viegas, V Carmona, E Ferreiro… - … Therapy-Nucleic Acids, 2020 - cell.com
Alzheimer's disease (AD) is the most common form of dementia worldwide, characterized by
progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness …
progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness …
MicroRNA-138 overexpression alters Aβ42 levels and behavior in wildtype mice
E Boscher, C Goupil, S Petry, R Keraudren… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
changes in cognitive and behavioral functions. With the exception or rare mutations in PSEN …
changes in cognitive and behavioral functions. With the exception or rare mutations in PSEN …
Targeting MicroRNA-485-3p blocks Alzheimer's disease progression
HS Koh, SJ Lee, HJ Lee, JW Min, T Iwatsubo… - International journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a form of dementia characterized by progressive memory
decline and cognitive dysfunction. With only one FDA-approved therapy, effective treatment …
decline and cognitive dysfunction. With only one FDA-approved therapy, effective treatment …
MicroRNA‐128 suppresses tau phosphorylation and reduces amyloid‐beta accumulation by inhibiting the expression of GSK3β, APPBP2, and mTOR in Alzheimer's …
Abstract Introduction and Aims Alzheimer's disease (AD) is characterized by the abnormal
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …
accumulation of hyperphosphorylated tau proteins and amyloid‐beta (Aβ) peptides. Recent …
MicroRNA-298 reduces levels of human amyloid-β precursor protein (APP), β-site APP-converting enzyme 1 (BACE1) and specific tau protein moieties
Alzheimer's disease (AD) is the most common age-related form of dementia, associated with
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …
deposition of intracellular neuronal tangles consisting primarily of hyperphosphorylated …
MicroRNA-149 is downregulated in Alzheimer's disease and inhibits β-amyloid accumulation and ameliorates neuronal viability through targeting BACE1
W Du, C Lei, Y Dong - Genetics and Molecular Biology, 2021 - SciELO Brasil
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) plays a critical role in
Alzheimer's disease (AD) pathogenesis. This study aimed to investigate the relationship …
Alzheimer's disease (AD) pathogenesis. This study aimed to investigate the relationship …
MicroRNA-140 silencing represses the incidence of Alzheimer's disease
C Liang, Y Mu, H Tian, D Wang, S Zhang, H Wang… - Neuroscience …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative condition leading to severe disability from
progressive impairments in cognitive functions including memory and learning. Non-coding …
progressive impairments in cognitive functions including memory and learning. Non-coding …
MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats
J Ai, LH Sun, H Che, R Zhang, TZ Zhang… - Journal of …, 2013 - Soc Neuroscience
Previous studies have demonstrated that chronic brain hypoperfusion (CBH) causes Aβ
aggregation by upregulating expression of amyloid precursor protein (APP) and β-site APP …
aggregation by upregulating expression of amyloid precursor protein (APP) and β-site APP …
[HTML][HTML] MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice
J Li, D Li, H Zhou, G Wu, Z He, W Liao, Y Li… - Aging (Albany NY …, 2020 - ncbi.nlm.nih.gov
MicroRNAs have become pivotal modulators in the pathogenesis of Alzheimer's disease.
MiR-338-5p is associated with neuronal differentiation and neurogenesis, and expressed …
MiR-338-5p is associated with neuronal differentiation and neurogenesis, and expressed …