Attempts to detect infectivity in the blood of humans and animals affected with transmissible
spongiform encephalopathies (TSEs or prion diseases) have often been inconclusive …

The emergence of variant Creutzfeld-Jakob disease, following on from the bovine
spongiform encephalopathy (BSE) epidemic, led to concerns about the potential risk of …

The host prion protein, PrPc, and its conformationally changed isoform, PrPsc, play an
essential role in the transmissible spongiform encephalopathy (TSE) infections. The prion …

Tissue homogenates of brain and spleen recovered from a sheep experimentally infected
with BSE by the oral route and another infected intracerebrally were injected into panels of …

It is now clearly established that the transfusion of blood from variant CJD (v-CJD) infected
individuals can transmit the disease. Since the number of asymptomatic infected donors …

Probable transmission of bovine spongiform encephalopathy to humans has focused
intense interest on all of the transmissible spongiform encephalopathies (TSEs) and how …

The cause of the original case or cases of bovine spongiform encephalopathy (BSE)
remains an enigma. Sheep scrapie or a previously undetected sporadic bovine …

Scrapie is a disease which occurs naturally in sheep and goats and belongs to a group of
neurodegenerative disorders known as transmissible spongiform encephalopathies, or …

The association between bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–
Jakob disease (vCJD) has demonstrated that cattle transmissible spongiform …

The development of diagnostic tools for transmissible spongiform encephalopathies (TSEs)
would greatly assist their study and may provide assistance in controlling the disease. The …