Therapeutic potential of TRPM8 channels in cancer treatment
SV Ochoa, Z Casas, SL Albarracín… - Frontiers in …, 2023 - frontiersin.org
Cancer is a multifactorial process associated with changes in signaling pathways leading to
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …
cell cycle variations and gene expression. The transient receptor potential melastatin 8 …
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
S Chen, L Bao, K Keefer, S Shanmughapriya… - Cell death & …, 2020 - nature.com
Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in
maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly …
maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly …
Suppression of trpm 7 inhibits proliferation, migration, and invasion of malignant human glioma cells
Background Glioblastoma multiforme (GBM) is the most common and aggressive primary
brain tumor with a dismal prognosis. Despite intensive study on tumor biology, the …
brain tumor with a dismal prognosis. Despite intensive study on tumor biology, the …
[HTML][HTML] N-Myc-induced up-regulation of TRPM6/TRPM7 channels promotes neuroblastoma cell proliferation
Z Zhang, M Faouzi, J Huang, D Geerts, H Yu, A Fleig… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Intracellular levels of the divalent cations Ca 2+ and Mg 2+ are important regulators of cell
cycle and proliferation. However, the precise mechanisms by which they are regulated in …
cycle and proliferation. However, the precise mechanisms by which they are regulated in …
[HTML][HTML] TRPM8 is required for survival and radioresistance of glioblastoma cells
D Klumpp, SC Frank, L Klumpp, EC Sezgin, M Eckert… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract TRPM8 is a Ca 2+-permeable nonselective cation channel belonging to the
melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly …
melastatin sub-group of the transient receptor potential (TRP) family. TRPM8 is aberrantly …
A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death
TRPM2 is a Ca 2+-permeable channel that is activated by oxidative stress and confers
susceptibility to cell death. Here, an isoform of TRPM2 was identified in normal human bone …
susceptibility to cell death. Here, an isoform of TRPM2 was identified in normal human bone …
The overexpressed functional transient receptor potential channel TRPM2 in oral squamous cell carcinoma
LY Zhao, WL Xu, ZQ Xu, C Qi, Y Li, J Cheng, LK Liu… - Scientific reports, 2016 - nature.com
TRPM2, one member of the transient receptor potential (TRP) protein super-family, is a
Ca2+-permeable channel that is activated by oxidative stress and confers susceptibility to …
Ca2+-permeable channel that is activated by oxidative stress and confers susceptibility to …
Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2‐independent and RACK1‐mediated mechanism of HIF‐1α stabilization
The growth adaptation of cancer cells to a hypoxic tumour microenvironment is mostly
regulated by hypoxia‐induced transcription factor HIF‐1. HIF‐1 transcriptional activity is …
regulated by hypoxia‐induced transcription factor HIF‐1. HIF‐1 transcriptional activity is …
Targeting TRPM2 channels impairs radiation‐induced cell cycle arrest and fosters cell death of T cell leukemia cells in a Bcl‐2‐dependent manner
D Klumpp, M Misovic, K Szteyn… - Oxidative medicine …, 2016 - Wiley Online Library
Messenger RNA data of lymphohematopoietic cancer lines suggest a correlation between
expression of the cation channel TRPM2 and the antiapoptotic protein Bcl‐2. The latter is …
expression of the cation channel TRPM2 and the antiapoptotic protein Bcl‐2. The latter is …