[HTML][HTML] TRPM7 induces tumorigenesis and stemness through notch activation in glioma
J Wan, AA Guo, P King, S Guo, T Saafir… - Frontiers in …, 2020 - frontiersin.org
We have reported that transient receptor potential melastatin-related 7 (TRPM7) regulates
glioma stem cells (GSC) growth and proliferation through Notch, STAT3-ALDH1, and CD133 …
glioma stem cells (GSC) growth and proliferation through Notch, STAT3-ALDH1, and CD133 …
[HTML][HTML] TRPM channels in human diseases
The transient receptor potential melastatin (TRPM) subfamily belongs to the TRP cation
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
channels family. Since the first cloning of TRPM1 in 1989, tremendous progress has been …
[HTML][HTML] Potential role of transient receptor potential (TRP) channels in bladder cancer cells
H Mizuno, Y Suzuki, M Watanabe, T Sokabe… - The journal of …, 2014 - Springer
Transient receptor potential (TRP) channels play important roles in thermal, chemical, and
mechanical sensation in various tissues. In this study, we investigated the differences in …
mechanical sensation in various tissues. In this study, we investigated the differences in …
PIP2 and PIP3 interact with N-terminus region of TRPM4 channel
K Bousova, M Jirku, L Bumba, L Bednarova, M Sulc… - Biophysical …, 2015 - Elsevier
The transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective
ion channel broadly expressed in a variety of tissues. Receptor has been identified as a …
ion channel broadly expressed in a variety of tissues. Receptor has been identified as a …
[HTML][HTML] Structural mechanism of TRPM7 channel regulation by intracellular magnesium
E Schmidt, C Narangoda, W Nörenberg… - Cellular and Molecular …, 2022 - Springer
Abstract Zn2+, Mg2+ and Ca2+ are essential divalent cations implicated in many metabolic
processes and signalling pathways. An emerging new paradigm is that the organismal …
processes and signalling pathways. An emerging new paradigm is that the organismal …
TRPM7 channels regulate glioma stem cell through STAT3 and Notch signaling pathways
M Liu, K Inoue, T Leng, S Guo, Z Xiong - Cellular signalling, 2014 - Elsevier
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in
adults with median survival time of 14.6 months. A small fraction of cancer stem cells (CSC) …
adults with median survival time of 14.6 months. A small fraction of cancer stem cells (CSC) …
[HTML][HTML] The TRPM6 kinase domain determines the Mg· ATP sensitivity of TRPM7/M6 heteromeric ion channels
Z Zhang, H Yu, J Huang, M Faouzi, C Schmitz… - Journal of Biological …, 2014 - ASBMB
The transient receptor potential melastatin member 7 (TRPM7) and member 6 (TRPM6) are
divalent cation channel kinases essential for magnesium (Mg 2+) homeostasis in …
divalent cation channel kinases essential for magnesium (Mg 2+) homeostasis in …
[HTML][HTML] TRPM5 mediates acidic extracellular pH signaling and TRPM5 inhibition reduces spontaneous metastasis in mouse B16-BL6 melanoma cells
T Maeda, A Suzuki, K Koga, C Miyamoto, Y Maehata… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Extracellular acidity is a hallmark of solid tumors and is associated with metastasis in the
tumor microenvironment. Acidic extracellular pH (pH e) has been found to increase …
tumor microenvironment. Acidic extracellular pH (pH e) has been found to increase …
[HTML][HTML] Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7
C Schmitz, AL Perraud, CO Johnson, K Inabe… - Cell, 2003 - cell.com
TRPM7 is a polypeptide with intrinsic ion channel and protein kinase domains whose
targeted deletion causes cells to experience growth arrest within 24 hr and eventually die …
targeted deletion causes cells to experience growth arrest within 24 hr and eventually die …
[HTML][HTML] The channel kinases TRPM6 and TRPM7 are functionally nonredundant
C Schmitz, MV Dorovkov, X Zhao, BJ Davenport… - Journal of Biological …, 2005 - ASBMB
TRPM7 and its closest homologue, TRPM6, are the only known fusions of an ion channel
pore with a kinase domain. Deletion of TRPM7 in DT40 B-lymphocytes causes growth arrest …
pore with a kinase domain. Deletion of TRPM7 in DT40 B-lymphocytes causes growth arrest …