The calcium‐permeable non‐selective cation channel TRPM2 is modulated by cellular acidification
JG Starkus, A Fleig, R Penner - The Journal of physiology, 2010 - Wiley Online Library
TRPM2 is a calcium‐permeable non‐selective cation channel expressed in the plasma
membrane and in lysosomes that is critically involved in aggravating reactive oxygen …
membrane and in lysosomes that is critically involved in aggravating reactive oxygen …
[HTML][HTML] TRPM2 promotes autophagic degradation in vascular smooth muscle cells
Transient receptor potential channel M2 (TRPM2) is a Ca2+-permeable channel that is
activated by reactive oxygen species (ROS). In many cell types, ROS activate TRPM2 to …
activated by reactive oxygen species (ROS). In many cell types, ROS activate TRPM2 to …
[HTML][HTML] Inactivation of TRPM7 kinase activity does not impair its channel function in mice
T Kaitsuka, C Katagiri, P Beesetty, K Nakamura… - Scientific reports, 2014 - nature.com
Transient receptor potential (TRP) family channels are involved in sensory pathways and
respond to various environmental stimuli. Among the members of this family, TRPM7 is a …
respond to various environmental stimuli. Among the members of this family, TRPM7 is a …
[HTML][HTML] Transient receptor potential mucolipin-1 channels in glioblastoma: role in patient's survival
MB Morelli, C Amantini, D Tomassoni, M Nabissi… - Cancers, 2019 - mdpi.com
A link between mucolipin channels and tumors has been recently suggested. Herein, we
aim to investigate the transient receptor potential mucolipin (TRPML)-1 relevance in …
aim to investigate the transient receptor potential mucolipin (TRPML)-1 relevance in …
Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity
S Voringer, L Schreyer, W Nadolni, MA Meier… - Oncogene, 2020 - nature.com
Myocardin-related transcription factors A and B (MRTFs) are coactivators of Serum
Response Factor (SRF) that mediates the expression of genes involved in cell proliferation …
Response Factor (SRF) that mediates the expression of genes involved in cell proliferation …
TRPM2: a multifunctional ion channel for calcium signalling
A Sumoza‐Toledo, R Penner - The Journal of physiology, 2011 - Wiley Online Library
The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …
[HTML][HTML] Mapping TRPM7 function by NS8593
V Chubanov, T Gudermann - International journal of molecular sciences, 2020 - mdpi.com
The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a
ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic …
ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic …
[HTML][HTML] TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway
S Almasi, BE Kennedy, M El-Aghil, AM Sterea… - Journal of Biological …, 2018 - ASBMB
A lack of effective treatment is one of the main factors contributing to gastric cancer–related
death. Discovering effective targets and understanding their underlying anti-cancer …
death. Discovering effective targets and understanding their underlying anti-cancer …
[HTML][HTML] TRPM2 oxidation activates two distinct potassium channels in melanoma cells through intracellular calcium increase
Tumor microenvironments are often characterized by an increase in oxidative stress levels.
We studied the response to oxidative stimulation in human primary (IGR39) or metastatic …
We studied the response to oxidative stimulation in human primary (IGR39) or metastatic …
Activation of TRPM7 channels by small molecules under physiological conditions
T Hofmann, S Schäfer, M Linseisen, L Sytik… - … -European Journal of …, 2014 - Springer
Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a cation
channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and …
channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and …