The calcium‐permeable non‐selective cation channel TRPM2 is modulated by cellular acidification

JG Starkus, A Fleig, R Penner - The Journal of physiology, 2010 - Wiley Online Library
TRPM2 is a calcium‐permeable non‐selective cation channel expressed in the plasma
membrane and in lysosomes that is critically involved in aggravating reactive oxygen …

[HTML][HTML] TRPM2 promotes autophagic degradation in vascular smooth muscle cells

Q Zhao, J Li, WH Ko, YW Kwan, L Jiang, L Sun… - Scientific reports, 2020 - nature.com
Transient receptor potential channel M2 (TRPM2) is a Ca2+-permeable channel that is
activated by reactive oxygen species (ROS). In many cell types, ROS activate TRPM2 to …

[HTML][HTML] Inactivation of TRPM7 kinase activity does not impair its channel function in mice

T Kaitsuka, C Katagiri, P Beesetty, K Nakamura… - Scientific reports, 2014 - nature.com
Transient receptor potential (TRP) family channels are involved in sensory pathways and
respond to various environmental stimuli. Among the members of this family, TRPM7 is a …

[HTML][HTML] Transient receptor potential mucolipin-1 channels in glioblastoma: role in patient's survival

MB Morelli, C Amantini, D Tomassoni, M Nabissi… - Cancers, 2019 - mdpi.com
A link between mucolipin channels and tumors has been recently suggested. Herein, we
aim to investigate the transient receptor potential mucolipin (TRPML)-1 relevance in …

Inhibition of TRPM7 blocks MRTF/SRF-dependent transcriptional and tumorigenic activity

S Voringer, L Schreyer, W Nadolni, MA Meier… - Oncogene, 2020 - nature.com
Myocardin-related transcription factors A and B (MRTFs) are coactivators of Serum
Response Factor (SRF) that mediates the expression of genes involved in cell proliferation …

TRPM2: a multifunctional ion channel for calcium signalling

A Sumoza‐Toledo, R Penner - The Journal of physiology, 2011 - Wiley Online Library
The transient potential receptor melastatin‐2 (TRPM2) channel has emerged as an
important Ca2+ signalling mechanism in a variety of cells, contributing to cellular functions …

[HTML][HTML] Mapping TRPM7 function by NS8593

V Chubanov, T Gudermann - International journal of molecular sciences, 2020 - mdpi.com
The transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a
ubiquitously expressed membrane protein, which forms a channel linked to a cytosolic …

[HTML][HTML] TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway

S Almasi, BE Kennedy, M El-Aghil, AM Sterea… - Journal of Biological …, 2018 - ASBMB
A lack of effective treatment is one of the main factors contributing to gastric cancer–related
death. Discovering effective targets and understanding their underlying anti-cancer …

[HTML][HTML] TRPM2 oxidation activates two distinct potassium channels in melanoma cells through intracellular calcium increase

L Ferrera, R Barbieri, C Picco, P Zuccolini… - International Journal of …, 2021 - mdpi.com
Tumor microenvironments are often characterized by an increase in oxidative stress levels.
We studied the response to oxidative stimulation in human primary (IGR39) or metastatic …

Activation of TRPM7 channels by small molecules under physiological conditions

T Hofmann, S Schäfer, M Linseisen, L Sytik… - … -European Journal of …, 2014 - Springer
Transient receptor potential cation channel, subfamily M, member 7 (TRPM7) is a cation
channel covalently linked to a protein kinase domain. TRPM7 is ubiquitously expressed and …