Cancer cachexia among patients with advanced non-small-cell lung cancer on immunotherapy: an observational study with exploratory gut microbiota analysis

T Hakozaki, A Nolin-Lapalme, M Kogawa, Y Okuma… - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy has revolutionized the therapeutic options for patients
living with non-small-cell lung cancer (NSCLC). Despite the unprecedented results achieved …

Effect of cancer-related cachexia and associated changes in nutritional status, inflammatory status, and muscle mass on immunotherapy efficacy and survival in …

C Madeddu, S Busquets, C Donisi, E Lai, A Pretta… - Cancers, 2023 - mdpi.com
Simple Summary Immune checkpoint inhibitor (ICI)-based immunotherapy has dramatically
improved the survival of patients with advanced non-small cell lung cancer (NSCLC); …

Impact of cancer cachexia on the therapeutic outcome of combined chemoimmunotherapy in patients with non-small cell lung cancer: a retrospective study

K Morimoto, J Uchino, T Yokoi, T Kijima, Y Goto… - …, 2021 - Taylor & Francis
Although previous studies suggest that cancer cachexia is a poor prognostic factor for
immune checkpoint inhibitor monotherapy, the impact of cancer cachexia on …

The role of a cachexia grading system in patients with non-small cell lung cancer treated with immunotherapy: implications for survival

JG Turcott, JE Martinez-Samano, AF Cardona… - Nutrition and …, 2021 - Taylor & Francis
Objective The association between cancer-induced weight-loss (CIWL) and poor clinical
outcomes in patients treated with immunotherapy is scarcely understood. We evaluated the …

Gut microbiota and dietary intervention: affecting immunotherapy efficacy in non–small cell lung cancer

Y Xin, CG Liu, D Zang, J Chen - Frontiers in Immunology, 2024 - frontiersin.org
Non–small cell lung cancer (NSCLC) accounts for 80–85% of all lung cancers. In recent
years, treatment with immune checkpoint inhibitors (ICIs) has gradually improved the …

Commensal microbiota contributes to predicting the response to immune checkpoint inhibitors in non‐small‐cell lung cancer patients

C Zhang, J Wang, Z Sun, Y Cao, Z Mu, X Ji - Cancer Science, 2021 - Wiley Online Library
Immunotherapy against cancer, through immune checkpoint inhibitors targeting the
programmed cell death‐1/programmed cell death‐ligand 1 axis, is particularly successful in …

Survival and biomarkers for cachexia in non‐small cell lung cancer receiving immune checkpoint inhibitors

D Murata, K Azuma, N Matsuo, K Murotani… - Cancer …, 2023 - Wiley Online Library
Background The presence of cachexia negatively impacts the prognosis of patients with
cancer. However, the mechanisms behind the development of cachexia and its prognostic …

Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients

Y Ni, Z Lohinai, Y Heshiki, B Dome, J Moldvay… - The ISME …, 2021 - academic.oup.com
Cachexia is associated with decreased survival in cancer patients and has a prevalence of
up to 80%. The etiology of cachexia is poorly understood, and limited treatment options …

Gut microbiome affects the response to immunotherapy in non‐small cell lung cancer

S Ren, L Feng, H Liu, Y Mao, Z Yu - Thoracic Cancer, 2024 - Wiley Online Library
Background Immunotherapy has revolutionized cancer treatment. Recent studies have
suggested that the efficacy of immunotherapy can be further enhanced by the influence of …

Gut microbiota diversity and specific composition during immunotherapy in responders with non-small cell lung cancer

F Shoji, M Yamaguchi, M Okamoto… - Frontiers in Molecular …, 2022 - frontiersin.org
Cancer immunotherapy including immune checkpoint inhibitors (ICI) has revolutionized non-
small cell lung cancer (NSCLC) therapy. Recently, the microbiota status “before” initiation of …