BACKGROUND: Biodegradable poly (lactide-co-glycolide)(PLGA) microspheres are a
promising carrier for vaccine delivery capable of maturing antigen-presenting cells to …

Purpose Allergen-specific immunotherapy (SIT) requires dozens of subcutaneous injections
over 3 to 5 years in order to control IgE-mediated hypersensitivity, which is a T-helper 2 …

Background Biodegradable microparticles, in particular poly (lactide‐co‐glycolide)(PLGA),
have been shown as potential delivery vehicles for intranasal (in) vaccines in animal …

Background: Two major drawbacks of current subcutaneous specific immunotherapy are the
risk to induce severe anaphylactic reactions and the need of multiple injections of the …

Background and objective Biocompatible and biodegradable microparticles have gained
interest as antigen delivery systems during the recent years. We investigated whether …

Previous studies demonstrated in vitro phagocytosis of poly (lactide-co-glycolide)(PLGA)
microspheres (MS) by macrophages and dendritic cells and the biodistribution of fluorescent …

Abstract Poly (lactide-co-glycolide)(PLGA) particles have strong potential as antigen delivery
systems. The size of PLGA particles used to vaccinate mice can affect the magnitude of the …

Priming with the major surface glycoprotein G of respiratory syncytial virus (RSV) expressed
by recombinant vaccinia leads to strong Th2 responses and lung eosinophilia during viral …

Ole e 1, the main allergen of the olive pollen, was entrapped in poly (dl-lactide glycolide)
microparticles by a solvent evaporation double emulsion technique. The physical properties …

Poly (lactide) and poly (lactide-co-glycolide) microspheres have been studied for controlled
antigen delivery and immune response enhancement for more than a decade. Early …